FD70

异硫氰酸荧光素-葡聚糖

Name: 异硫氰酸荧光素-葡聚糖
Brand: SIGMA

average M_w 59,000-77,000

别名:

FITC-右旋糖酐

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化学文摘社编号:

60842-46-8

UNSPSC Code:

12352201

NACRES:

NA.25

MDL number:

MFCD00131092

主要文件

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biological source

bacterial (Leuconostoc mesenteroides)

conjugate

FITC conjugate

form

powder

mol wt

average M_w 59,000-77,000

extent of labeling

0.001-0.020 mol FITC per mol glucose

color

light yellow to dark orange

solubility

water: 25 mg/mL

storage temp.

2-8°C

Quality Level

100

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General description

葡聚糖是一种无水葡萄糖聚合物。由大约 95% 的α-D-(166)键组成。其余的 a (163) 键构成了葡聚糖的分支。分支长度相互矛盾的数据表明平均分支长度小于 3 个葡萄糖单位。但是，其他方法研究表明存在大于 50 个葡萄糖单位的分支。已发现天然葡聚糖的分子量 (MW) 范围为 900 万至 5 亿。较低分子量的葡聚糖具有略少的支化，并具有更窄的分子量分布范围。分子量大于10,000 的葡聚糖似乎是高度分支化的。随着分子量的增加，葡聚糖分子的对称性增强。具有 2,000 至 10,000 分子量的葡聚糖表现出可膨胀线圈的特性。在分子量低于 2,000 时，葡聚糖更像棒状。葡聚糖的分子量可以通过以下一种或多种方法测定：低角度激光散射、尺寸排阻色谱法、铜络合和蒽酮试剂显色还原末端糖的测定和粘度。

Application

FITC-葡聚糖已用于心血管、微循环、灌注、细胞单层和细胞膜通透性研究，作为可支持血流、膜损伤、血管引流和肾脏消除等过程进行测量的荧光通量示踪剂化合物。小的 FITC-葡聚糖已用于对内吞作用和细胞连接渗透性等过程进行测量。70kDa 的 FITC-葡聚糖（FD-70）可用作开发将分子递送到原生质体中的模型化合物，并研究从水凝胶、脂质体等结构中释放药物的方法。它可用于微血管和细胞单层渗透性研究。

FITC-葡聚糖被广泛用于利用微荧光法对微循环和细胞渗透性的研究。 FITC-葡聚糖已用于研究植物细胞壁的孔隙率和毛细管渗透性。血浆蛋白已被显示不可与FITC-葡聚糖进行结合。

用异硫氰酸荧光素标记的葡聚糖可用于动物的灌注研究。

Packaging

无底玻璃瓶。内含物装在插入的融合锥内。

Preparation Note

Sigma 通常在水中以 25mg/ml 或更高的浓度对 FITC 葡聚糖的溶解进行检测。溶液应避光保存。FITC-葡聚糖在体内可稳定超过 24 小时。

Other Notes

为了全面了解我们针对客户研究提供的各种葡聚糖产品，建议您访问我们的碳水化合物分类页面。

pictograms

GHS07

signalword

Warning

hcodes

H315,H319,H335

pcodes

P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Acute liver failure enhances oral plasma exposure of zidovudine in rats by downregulation of hepatic UGT2B7 and intestinal P-gp.

Fan Wang et al.

Acta pharmacologica Sinica, 38(11), 1554-1565 (2017-08-05)

HIV infection is often associated with liver failure, which alters the pharmacokinetics of many drugs. In this study we investigated whether acute liver failure (ALF) altered the pharmacokinetics of the first-line anti-HIV agent zidovudine (AZT), a P-gp/BCRP substrate, in rats.

Compact ultrafast semiconductor disk laser: targeting GFP based nonlinear applications in living organisms.

Rodrigo Aviles-Espinosa et al.

Biomedical optics express, 2(4), 739-747 (2011-04-13)

We present a portable ultrafast Semiconductor Disk Laser (SDL) (or vertical extended cavity surface emitting laser-VECSELs), to be used for nonlinear microscopy. The SDL is modelocked using a quantum-dot semiconductor saturable absorber mirror (SESAM), delivering an average output power of

Formation of fenestrae in murine liver sinusoids depends on plasmalemma vesicle-associated protein and is required for lipoprotein passage.

Leonie Herrnberger et al.

PloS one, 9(12), e115005-e115005 (2014-12-30)

Liver sinusoidal endothelial cells (LSEC) are characterized by the presence of fenestrations that are not bridged by a diaphragm. The molecular mechanisms that control the formation of the fenestrations are largely unclear. Here we report that mice, which are deficient

Characterization of TSET, an ancient and widespread membrane trafficking complex.

Jennifer Hirst et al.

eLife, 3, e02866-e02866 (2014-05-29)

The heterotetrameric AP and F-COPI complexes help to define the cellular map of modern eukaryotes. To search for related machinery, we developed a structure-based bioinformatics tool, and identified the core subunits of TSET, a 'missing link' between the APs and

Imipenem and normal saline with cyclophosphamide have positive effects on the intestinal barrier in rats with sepsis.

Junting Yang et al.

Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia, 162(2), 90-98 (2018-06-24)

Sepsis is a life-threatening organ dysfunction caused the dysregulation of host inflammatory response and immunosuppression to infection Early recognition and intervention are hence of paramount importance. In this respect the "sepsis bundle" was proposed in 2004 to be instituted in

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FITC-labelled polysaccharides

Explore FITC-labelled polysaccharides and their properties, including impact of molecular weight on molecule dimensions.

FITC标记多糖

包括FITC-葡聚糖、FITC-DEAE-葡聚糖(FDD)、FITC-羧甲基 - 葡聚糖（FCM-葡聚糖）在内的FITC标记多糖的补充信息。本页面主要介绍了重均分子量对于对应分子尺寸和其他物理性质的影响

异硫氰酸荧光素-葡聚糖

average Mw 59,000-77,000

选择尺寸

关于此项目

主要文件

属性

biological source

conjugate

form

mol wt

extent of labeling

color

solubility

storage temp.

Quality Level

相关类别

说明

General description

Application

Packaging

Preparation Note

Other Notes

安全信息

pictograms

signalword

hcodes

pcodes

Hazard Classifications

target_organs

存储类别

wgk

flash_point_f

flash_point_c

ppe

文件

分析证书(COA)

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average M_w 59,000-77,000