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Merck
CN

G110

胍那苄 乙酸盐

α2 adrenoceptor agonist, powder

别名:

1-(2,6-二氯亚苄基氨基)胍 乙酸盐, WY-8678

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关于此项目

经验公式（希尔记法）:
C8H8Cl2N4 · C2H4O2
化学文摘社编号:
23256-50-0
分子量:
291.13
NACRES:
NA.77
PubChem Substance ID:
24277775
UNSPSC Code:
12352200
EC Number:
245-534-7
MDL number:
MFCD00153801

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产品名称

胍那苄 乙酸盐, powder

InChI key

MCSPBPXATWBACD-GAYQJXMFSA-N

InChI

1S/C8H8Cl2N4.C2H4O2/c9-6-2-1-3-7(10)5(6)4-13-14-8(11)12;1-2(3)4/h1-4H,(H4,11,12,14);1H3,(H,3,4)/b13-4+;

SMILES string

CC(O)=O.NC(=N)N\N=C\c1c(Cl)cccc1Cl

form

powder

color

white

solubility

H2O: 10 mg/mL, alcohol: 50 mg/mL

originator

Wyeth

Quality Level

200

Gene Information

human ... ADRA2A(150), ADRA2B(151), ADRA2C(152)

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相关类别

Biochem/physiol Actions

中枢作用的α2 肾上腺素能受体激动剂；I2 咪唑啉结合位点配体；抗高血压活性。

Features and Benefits

《受体分类和信号转导》手册的 α2-肾上腺素受体 以及 咪唑啉结合位点 页面有该化合物的介绍。想要浏览手册的其他页面， 请单击此处。
该化合物由 Wyeth 开发 。要浏览其他制药公司开发的化合物列表批准的药物/候选药物的列表， 点击这里 。
这种化合物是神经科学研究的特色产品。点击此处发现更多特色神经科学产品。在sigma.com/discover-bsm可了解更多关于生物活性小分子的其他研究领域。

pictograms

Skull and crossbones
GHS06

signalword

Danger

hcodes

H301

Hazard Classifications

Acute Tox. 3 Oral

存储类别

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000530856
0000530855
0000530856
0000530855
0000523790

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Pavel Tsaytler et al.
Science (New York, N.Y.), 332(6025), 91-94 (2011-03-10)
Many biological processes are regulated through the selective dephosphorylation of proteins. Protein serine-threonine phosphatases are assembled from catalytic subunits bound to diverse regulatory subunits that provide substrate specificity and subcellular localization. We describe a small molecule, guanabenz, that bound to
Fabienne Gug et al.
Bioconjugate chemistry, 21(2), 279-288 (2010-01-23)
The synthesis of affinity matrices for 6-aminophenanthridine (6AP) and 2,6-dichlorobenzylidenaminoguanidine (Guanabenz, GA), two unrelated prion inhibitors, is described. In both cases, the same simple spacer, epsilon-aminocaproylaminopentanol, was introduced by a Mitsunobu reaction and the choice of the anchoring position of
Pavel Tsaytler et al.
The FEBS journal, 280(2), 766-770 (2012-02-22)
Selective and reversible phosphorylation is one of the most common post-translational modifications of proteins. Although kinase inhibitors are popular in drug development programmes, selective pharmacological manipulation of phosphatase activity has been challenging to achieve. We review recent advances in the
B Holmes et al.
Drugs, 26(3), 212-229 (1983-09-01)
Guanabenz is an orally active central alpha 2-adrenoceptor agonist. Its antihypertensive action is thought to result from a decrease in sympathetic outflow from the brain to the peripheral circulatory system as a result of stimulation of central alpha 2-adrenoceptors. In
Suzana Dos Reis et al.
Biochimie, 93(6), 1047-1054 (2011-03-15)
The ribosome, the protein synthesis machinery of the cell, has also been implicated in protein folding. This activity resides within the domain V of the main RNA component of the large subunit of the ribosome. It has been shown that
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