G3295
GW0742
≥98% (HPLC), selective PPARδ agonist, powder
别名:
[4-[[[2-[3-氟-4-(三氟甲基)苯基]-4-甲基-5-噻唑基]甲基]硫代]-2-甲基苯氧基]乙酸
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关于此项目
经验公式（希尔记法）:
C21H17F4NO3S2
化学文摘社编号:
分子量:
471.49
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77
产品名称
GW0742, ≥98% (HPLC)
质量水平
方案
≥98% (HPLC)
表单
powder
颜色
white
mp
134.5-135.5 °C
溶解性
DMSO: >5 mg/mL
H2O: insoluble
创始人
GlaxoSmithKline
储存温度
2-8°C
SMILES字符串
Cc1cc(SCc2sc(nc2C)-c3ccc(c(F)c3)C(F)(F)F)ccc1OCC(O)=O
InChI
1S/C21H17F4NO3S2/c1-11-7-14(4-6-17(11)29-9-19(27)28)30-10-18-12(2)26-20(31-18)13-3-5-15(16(22)8-13)21(23,24)25/h3-8H,9-10H2,1-2H3,(H,27,28)
InChI key
HWVNEWGKWRGSRK-UHFFFAOYSA-N
基因信息
human ... PPARA(5465), PPARD(5467), PPARG(5468)
相关类别
生化/生理作用
GW0742是一种高度选择性的PPARδ激动剂。
GW0742是一种高度选择性的PPARδ激动剂。 EC50 = 1 nM ，对PPARα和PPARγ的EC50分别为1 μM和2 μM。
特点和优势
该化合物由GlaxoSmithKline开发。要浏览其他药物开发化合物和批准的药物/候选药物列表，单击此处。
法律信息
根据GlaxoSmithKline的协议出售用于研究目的
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Bruce E Heck et al.
Cell transplantation, 26(8), 1405-1417 (2017-09-14)
Osteoarthritis (OA) is an inflammatory joint disease characterized by degeneration of articular cartilage within synovial joints. An estimated 27 million Americans suffer from OA, and the population is expected to reach 67 million in the United States by 2030. Thus
Haruyo Yagi et al.
Stem cell research & therapy, 11(1), 293-293 (2020-07-19)
There have been limited advances in the treatment of bone and joint infections, which currently involves a combination of surgery and antibiotic administration. There is a timely need in orthopedics to develop more effective and less invasive forms of antimicrobial
Koichiro Kawaguchi et al.
FEBS open bio, 6(3), 190-199 (2016-04-06)
Fatty acid-binding proteins (FABPs) are responsible for binding and storing hydrophobic ligands such as long-chain fatty acids, and for transporting these ligands to the appropriate compartments within the cell. The present study demonstrates that the FABP5 gene is upregulated in
Amar Bahadur Singh et al.
The Journal of biological chemistry, 292(3), 884-897 (2016-12-04)
Peroxisome proliferator-activated receptor δ (PPARδ) regulates many genes involved in lipid metabolism. Hepatic lysophosphatidylcholine acyltransferase 3 (LPCAT3) has critical functions in triglycerides transport and endoplasmic reticulum stress response due to its unique ability to catalyze the incorporation of polyunsaturated fatty
Daniel Morales-Cano et al.
Clinical science (London, England : 1979), 130(20), 1823-1836 (2016-07-15)
PPARβ/δ activation protects against endothelial dysfunction in diabetic models. Elevated glucose is known to impair cAMP-induced relaxation and Kv channel function in coronary arteries (CA). Herein, we aimed to analyse the possible protective effects of the PPARβ/δ agonist GW0742 on
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