G5038
Anti-GAD65 Antibody
rabbit polyclonal
别名:
抗-GAD 65
登录 查看组织和合同定价。
选择尺寸
关于此项目
Conjugate:
unconjugated
Clone:
polyclonal
Application:
ARR, IHC (p), WB
Citations:
15
产品名称
抗谷氨酸脱羧酶65（5-22） 兔抗, IgG fraction of antiserum, buffered aqueous solution
biological source
rabbit
conjugate
unconjugated
antibody form
IgG fraction of antiserum
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
species reactivity
human, mouse, rat, pig, monkey
enhanced validation
independent
Learn more about Antibody Enhanced Validation
technique(s)
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:1,000 using tissue sections of rat pancreas., microarray: suitable, western blot: 1:4,000 using rat brain extract
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... GAD2(2572)
mouse ... Gad2(14417)
rat ... Gad2(24380)
正在寻找类似产品? 访问 产品对比指南
General description
GAD主要在中枢神经紧张的系统（CNS）和胰岛中表达。它也在睾丸，输卵管和卵巢中表达。GAD存在于GAD65和GAD67这两个异构体中。GAD65靶向膜和神经末梢。
Immunogen
对应于人GAD 65的N-末端区域（氨基酸5-22）的合成肽。该序列在大鼠和猪GAD 65（单个氨基酸取代）以及小鼠和猴GAD 65中高度保守，但在GAD 67中未发现。
Application
兔抗谷氨酸脱羧酶 65（5-22）抗体还可用于免疫组化和免疫细胞化学。
Biochem/physiol Actions
与GAD 65（65 kDa）发生特异性反应。
谷氨酸脱羧酶（GAD）催化L-谷氨酸向γ-氨基丁酸（GABA）的转化，这是大脑中主要抑制性神经递质，并且是胰岛中假定的旁分泌信号分子。GAD65是一种嗜酸性，膜锚定的蛋白（585个氨基酸残基），编码在人类10号染色体上。它已被鉴定为胰岛素依赖型糖尿病（IDDM）和僵人综合征（SMS）中的自身抗原，并且可以作为IDDM早期阶段的标志物。GAD 65合成递质GABA用于囊泡释放。
Physical form
0.01M 磷酸缓冲盐溶液，pH 7.4，含 15mM 叠氮化钠。
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
未找到合适的产品？
试试我们的产品选型工具.
存储类别
10 - Combustible liquids
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
低风险生物材料
常规特殊物品
此项目有
Regulatory cytokine production stimulated by DNA vaccination against an altered form of glutamic acid decarboxylase 65 in nonobese diabetic mice
Glinka Y, et al.
Journal of Molecular Medicine, 81(3), 175-184 (2003)
mu Neurocircuitry: Establishing in vitro models of neurocircuits with human neurons
Fantuzzo JA, et al.
Technology, 5(02), 87-97 (2017)
Toshio Kosaka et al.
Neuroscience research, 157, 15-33 (2019-10-21)
The structural features of dopamine (DA)-GABAergic neurons in the mouse main olfactory bulbs were examined, using both wild type and transgenic TH-GFP mice, with the combination of several methods; the immunocytochemistry, biotinylated dextran amine labeling, lucifer yellow injection in fixed
M G Erlander et al.
Neurochemical research, 16(3), 215-226 (1991-03-01)
Studies of the GABA-synthetic enzyme glutamate decarboxylase (glutamic acid decarboxylase; GAD; E.C.4.1.1.15) began in 1951 with the work of Roberts and his colleagues. Since then, many investigators have demonstrated the structural and functional heterogeneity of brain GAD. At least part
N J Tillakaratne et al.
Journal of neurochemistry, 58(2), 618-627 (1992-02-01)
gamma-Aminobutyric acid (GABA) and its synthetic enzyme, glutamate decarboxylase (GAD), are not limited to the nervous system but are also found in nonneural tissues. The mammalian brain contains at least two forms of GAD (GAD67 and GAD65), which differ from
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持