产品名称
单克隆抗-谷氨酸脱羧酶 67（GAD67） 小鼠抗, clone K-87, purified antibody
biological source
mouse
conjugate
unconjugated
antibody form
purified antibody
antibody product type
primary antibodies
clone
K-87, monoclonal
mol wt
antigen 67 kDa
species reactivity
rat, mouse, human
concentration
~1 mg/mL
technique(s)
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:500-1:20,000 (with antigen-retrieval step)
western blot: 1:500-1:20,000 using mouse brain extract
isotype
IgG1κ
UniProt accession no.
shipped in
dry ice
storage temp.
−70°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... GAD1(2571)
mouse ... Gad1(14415)
rat ... Gad1(24379)
Application
小鼠抗谷氨酸脱羧酶67（GAD67）单克隆抗体已被用于：
- 免疫组织荧光
- 蛋白质印迹
- 免疫组织化学。
抗谷氨酸脱羧酶 67（GAD67）单克隆抗体适用于免疫印迹、免疫印迹（1：500-1：20,000 稀释，小鼠脑提取物）和免疫组化（1：500-1：20,000 稀释，小鼠脑切片）。
Biochem/physiol Actions
与 GAD67 特异性反应。不与 GAD65 发生交叉反应。
谷氨酸脱羧酶67（GAD67）涉及 γ-氨基丁酸 (GABA)的生产，氨基丁酸是中枢神经系统 (CNS)中的一种抑制性神经递质。GAD67缺乏会导致精神病、精神分裂和双向情感障碍。
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
General description
谷氨酸脱羧酶67（GAD67）由基因谷氨酸脱羧酶1（GAD1）编码。GAD1基因位于人染色体2q31.1。GAD67位于树突和细胞体。
Immunogen
来自小鼠 GAD67 的合成肽（氨基酸 87-106）。
该肽与 GAD65 不具有同源性。
Physical form
在含有 0.01％ 叠氮化钠的磷酸盐缓冲盐水中的溶液。
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存储类别
10 - Combustible liquids
wgk
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
法规信息
常规特殊物品
此项目有
Minjung Kim et al.
PloS one, 7(2), e32043-e32043 (2012-03-01)
The analysis of co-localized protein expression in a tissue section is often conducted with immunofluorescence histochemical staining which is typically visualized in localized regions. On the other hand, chromogenic immunohistochemical staining, in general, is not suitable for the detection of
Mitsuhiro Tsuboi et al.
Cancer medicine, 8(9), 4189-4199 (2019-06-18)
In a previous genome-wide screening, we identified hypermethylated CpG islands around glutamate decarboxylase 1 (GAD1) in lung adenocarcinoma (LADC). In this study, we aimed to investigate the methylation and expression status of GAD1 and its prognostic value in patients with
Baohu Ji et al.
PloS one, 8(6), e66327-e66327 (2013-07-05)
It has been well established that schizophrenia patients display impaired NMDA receptor (NMDAR) functions as well as exacerbation of symptoms in response to NMDAR antagonists. Abnormal NMDAR signaling presumably contributes to cognitive deficits which substantially contribute to functional disability in
Silvia Rossi et al.
Brain, behavior, and immunity, 25(5), 947-956 (2010-10-14)
Synaptic dysfunction triggers neuronal damage in experimental autoimmune encephalomyelitis (EAE), a model of multiple sclerosis (MS). While excessive glutamate signaling has been reported in the striatum of EAE, it is still uncertain whether GABA synapses are altered. Electrophysiological recordings showed
Ying Chen et al.
Neuropharmacology, 60(7-8), 1075-1087 (2010-09-28)
GAD67 corresponds to one of two enzymes that decarboxylates glutamate to produce γ-aminobutyric acid, the main inhibitory neurotransmitter in the mammalian central nervous system, hence defining the cellular phenotype of a diverse set of inhibitory interneurons of the brain. Reduced
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