G5668
GW1929 水合物
>98% (HPLC), solid
别名:
水合物
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关于此项目
经验公式（希尔记法）:
C30H29N3O4 · xH2O
化学文摘社编号:
分子量:
495.57 (anhydrous basis)
MDL number:
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
产品名称
GW1929 水合物, >98% (HPLC), solid
SMILES string
[H]O[H].CN(CCOc1ccc(C[C@H](Nc2ccccc2C(=O)c3ccccc3)C(O)=O)cc1)c4ccccn4
InChI
1S/C30H29N3O4.H2O/c1-33(28-13-7-8-18-31-28)19-20-37-24-16-14-22(15-17-24)21-27(30(35)36)32-26-12-6-5-11-25(26)29(34)23-9-3-2-4-10-23;/h2-18,27,32H,19-21H2,1H3,(H,35,36);1H2/t27-;/m0./s1
InChI key
XSITZVFUXCLFMK-YCBFMBTMSA-N
assay
>98% (HPLC)
form
solid
solubility
DMSO: 20 mg/mL
originator
GlaxoSmithKline
Quality Level
Gene Information
human ... PPARG(5468)
相关类别
Application
GW1929已被用作过氧化物酶体增殖物激活受体γ (PPARγ) 配体：
- 研究对参与脂肪生成的植物同源结构域指蛋白16 (Phf16)和含patatin样磷脂酶域3 (Pnpla3)表达的影响
- 研究对人肝癌细胞补体成分3 (C3)基因表达的影响
- 激活人乳腺癌细胞中的PPARγ
Biochem/physiol Actions
GW1929 是 PPAR-γ 的高亲和力激动剂。
GW1929是非噻唑烷二酮，参与细胞生长抑制和调控基因表达。通过DNA片段化对全脑缺血-再灌注损伤具有神经保护作用，可减轻炎症反应。GW1929参与抑制α7 N-乙酰胆碱受体表达和启动子活性。它还影响早期生长反应-1 (Egr-1)蛋白的表达。
Features and Benefits
Legal Information
根据与葛兰素史克公司达成的协议，销售仅限于研究目的
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Miaozhen Pan et al.
Experimental eye research, 202, 108332-108332 (2020-11-06)
Form deprivation myopia (FDM) is characterized by loss of choroidal thickness (ChT), reduced choroidal blood perfusion (ChBP), and consequently scleral hypoxia. In some tissues, changes in levels of peroxisome proliferator-activated receptor γ (PPARγ) expression modulate hypoxia-induced pathological responses. We determined
Seo-Hyuk Chang et al.
Journal of cellular biochemistry, 120(3), 3599-3610 (2018-10-03)
Adipocyte differentiation is controlled by multiple signaling pathways. To identify new adipogenic factors, C3H10T1/2 adipocytes were treated with previously known antiadipogenic phytochemicals (resveratrol, butein, sulfuretin, and fisetin) for 24 hours. Commonly regulated genes were then identified by transcriptional profiling analysis. Three
Swei Sunny Hahn et al.
Cellular signalling, 26(4), 730-739 (2014-01-15)
Studies demonstrated that peroxisome proliferator-activated receptor gamma (PPARγ) ligands reduce nicotine-induced non small cell lung carcinoma (NSCLC) cell growth through inhibition of nicotinic acetylcholine receptor (nAChR) mediated signaling pathways. However, the mechanisms by which PPARγ ligands inhibited nAChR expression remain
Ravinder K Kaundal et al.
Behavioural brain research, 216(2), 606-612 (2010-09-14)
Transient global cerebral ischemia results in acute neurodegeneration in selective brain areas. Global cerebral ischemic-reperfusion (IR) injury induced selective hippocampal damage results into various neurobehavioral deficits including spatial memory and learning deficiencies. In this study, we have investigated the protective
Vladimir S Shavva et al.
European journal of cell biology, 97(3), 204-215 (2018-03-20)
C3 is an acute phase protein, and thus its plasma concentration increases quickly and drastically during the onset of inflammation. Insulin plays a complex role in inflammation. Elevated level of plasma C3 was shown to correlate with heightened fasting insulin
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