G5671
抗半乳凝素-8抗体，小鼠单克隆
~1.0 mg/mL, clone VA-11.25, purified from hybridoma cell culture
别名:
抗Gal-8, 抗LGALS8, 抗PCTA1, 抗凝集素，半乳糖苷结合，可溶，8, 抗前列腺癌肿瘤抗原1
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关于此项目
NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
VA-11.25, monoclonal
Application:
ELISA (i), ICC, WB
Citations:
7
biological source
mouse
conjugate
unconjugated
antibody form
purified from hybridoma cell culture
antibody product type
primary antibodies
clone
VA-11.25, monoclonal
form
buffered aqueous solution
mol wt
antigen ~34 kDa
species reactivity
mouse, rat, human
concentration
~1.0 mg/mL
technique(s)
immunocytochemistry: suitable, indirect ELISA: suitable, western blot: 1-2 μg/mL using rat galectin 8 recombinant protein
isotype
IgM
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... LGALS8(3964)
mouse ... Lgals8(56048)
rat ... Lgals8(116641)
General description
半乳凝素特异性结合β-半乳糖苷。目前已发现15种哺乳动物半乳凝素。半乳凝素8含有两个由短肽连接的CRD结构。
抗-半乳凝素8（小鼠IgM亚型）单克隆抗体来自于小鼠骨髓瘤细胞和重组大鼠半乳凝素8免疫的BALB/c小鼠脾细胞融合而VA-11.25杂交瘤细胞。半乳凝素属于糖类结合蛋白家族。就这一家族的蛋白而言，半乳凝素8的独特性在于通过同一基因编码出多种形式的蛋白。
Immunogen
重组大鼠半乳凝素8。
Application
小鼠抗半乳凝素-8抗体已用于：
- 免疫印迹
- 免疫细胞化学
- 酶联免疫吸附测定(ELISA)
Biochem/physiol Actions
半乳凝素(Galectin)属糖结合蛋白家族。这类蛋白在富含N-乙酰乳糖胺复合糖的糖识别域(CRD)和特异性上具有相似性。半乳凝素与糖类的结合可调控细胞增殖、死亡和迁移，参与癌症发生发展。半乳凝素8是一种分泌型蛋白质，两个CRD结构域需要同时激活才能调节细胞黏附。它可与整合素形成复合物，启动整合素介导的信号级联放大。与之相反的是，过量蛋白会通过与整合素相互作用而负性调节细胞黏附。这些半乳凝素8相关信号有助于确定可进行细胞黏附和迁移的区域。它可能参与肿瘤转化。
本抗体与半乳凝素3和半乳凝素9的交叉反应性较低。
Physical form
溶于0.01 M磷酸盐缓冲液（pH 7.4）中，含有15 mM叠氮化钠。
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存储类别
10 - Combustible liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
法规信息
低风险生物材料
常规特殊物品
常规特殊物品
此项目有
G A Rabinovich
Cell death and differentiation, 6(8), 711-721 (1999-09-01)
Galectins constitute a family of evolutionarily conserved animal lectins, which are defined by their affinity for poly-N-acetyllactosamine-enriched glycoconjugates and sequence similarities in the carbohydrate recognition domain. During the past decade, attempts to dissect the functional role for galectins in vivo
Laurent Ingrassia et al.
Current medicinal chemistry, 13(29), 3513-3527 (2006-12-16)
Galectins form a family of carbohydrate-binding proteins defined by their affinity for beta-galactosides containing glycoconjugates. The carbohydrate recognition domain (CRD) is responsible for the specificity of galectins for saccharides. This binding may result in modulated cell proliferation, cell death and
Human galectin-8 isoforms and cancer
Bidon WN and Le Pennec JP
Glycoconjugate Journal, 19(7-9), 557-563 (2002)
Y Levy et al.
The Journal of biological chemistry, 276(33), 31285-31295 (2001-05-24)
The interaction of cells with the extracellular matrix regulates cell adhesion and motility. Here we demonstrate that different cell types adhere and spread when cultured in serum-free medium on immobilized galectin-8, a mammalian beta-galactoside-binding protein. At maximal doses, galectin-8 is
Hitomi Yamamoto et al.
Journal of biochemistry, 143(3), 311-324 (2007-11-21)
We previously showed that tandem-repeat type galectin-8, which has two covalently linked carbohydrate recognition domains (CRDs), induces neutrophil-adhesion through binding to integrin alphaM. Here, we analysed the function of galectin-8 in Jurkat T-cells. Galectin-8, as well as tandem-repeat galectin-9, and
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