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Merck
CN

G6295

GW3965 盐酸盐

≥98% (HPLC), powder, liver X receptors agonist

别名:

3- [3- [N-（2-氯-3-三氟甲基苄基） - （2,2-二苯乙基）氨基]丙氧基]苯乙酸 盐酸盐

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关于此项目

经验公式（希尔记法）:
C33H31F3ClNO3 · HCl
化学文摘社编号:
405911-17-3
分子量:
618.51
UNSPSC Code:
12352200
PubChem Substance ID:
24724494
NACRES:
NA.77
MDL number:
MFCD08276920

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产品名称

GW3965 盐酸盐, ≥98% (HPLC), powder

SMILES string

Cl[H].OC(=O)Cc1cccc(OCCCN(CC(c2ccccc2)c3ccccc3)Cc4cccc(c4Cl)C(F)(F)F)c1

InChI key

NMPUWJFHNOUNQU-UHFFFAOYSA-N

InChI

1S/C33H31ClF3NO3.ClH/c34-32-27(15-8-17-30(32)33(35,36)37)22-38(18-9-19-41-28-16-7-10-24(20-28)21-31(39)40)23-29(25-11-3-1-4-12-25)26-13-5-2-6-14-26;/h1-8,10-17,20,29H,9,18-19,21-23H2,(H,39,40);1H

assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

white

solubility

DMSO: ≥20 mg/mL

originator

GlaxoSmithKline

Quality Level

100

相关类别

Biochem/physiol Actions

GW3965是hLXRα和hLXRβ上的肝X受体完全激动剂。 在 LXRα 的无细胞配体感应测定中，GW3965 具有 EC 50 = 125 nM和并且在在基于细胞的测定中作为hLXRα和hLXRβ的完全激动剂分布， EC 50 = 190 nM 和 30 nM 。在小鼠中具有口服活性。当针对一组核受体进行筛选时，它只与孕烷 X 受体 (PXR) 发生交叉反应。文献激动剂 T0901317 (Tularik) 在无细胞和基于细胞的测定分别有 EC 50 = 60 nM 和 85 nM。
GW3965是基于细胞的测定中hLXRα和hLXRβ的肝X受体完全激动剂，EC 50 = 190 nM 和 30 nM。

Features and Benefits

该化合物由GlaxoSmithKline开发。要浏览其他药物开发化合物和批准的药物/候选药物列表，单击此处。
这种化合物是基因调控研究的特色产品。点击此处发现更多特色基因调控产品。在sigma.com/discover-bsm可了解更多关于生物活性小分子的其他研究领域。

pictograms

CorrosionExclamation mark
GHS05,GHS07

signalword

Danger

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Chronic 4 - Eye Dam. 1

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000466377
0000413075
0000413075
0000223098
0000223100

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