G6793
GW7647
≥98% (HPLC), Potent human PPARα agonist
别名:
2-(4-(2-(1-环己烷丁基)-3-环己基脲基)乙基)苯硫基)-2-甲基丙酸
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关于此项目
经验公式（希尔记法）:
C29H46N2O3S
化学文摘社编号:
分子量:
502.75
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
Assay:
≥98% (HPLC)
Quality level:
产品名称
GW7647, ≥98% (HPLC)
SMILES string
CC(C)(Sc1ccc(CCN(CCCCC2CCCCC2)C(=O)NC3CCCCC3)cc1)C(O)=O
InChI key
PKNYXWMTHFMHKD-UHFFFAOYSA-N
InChI
1S/C29H46N2O3S/c1-29(2,27(32)33)35-26-18-16-24(17-19-26)20-22-31(28(34)30-25-14-7-4-8-15-25)21-10-9-13-23-11-5-3-6-12-23/h16-19,23,25H,3-15,20-22H2,1-2H3,(H,30,34)(H,32,33)
assay
≥98% (HPLC)
color
white
solubility
DMSO: soluble 16 mg/mL
H2O: insoluble
Quality Level
Gene Information
human ... PPARA(5465)
Application
GW7647已被用作过氧化物酶体增殖物激活受体α (PPAR α)配体：
- 脱脂培养基，用于治疗原代人肝细胞
- 测试对心肌细胞糖酵解功能的影响
- 测试对幼鼠心脏的影响
- 在乳腺癌MDA-MB-231细胞中激活PPAR
Biochem/physiol Actions
GW7647可降低血清甘油三酯水平，提高β-氧化相关基因的肝脏表达。GW7647与二甲双胍联合应用可提高肝脏脂肪变性或损伤情况下血清中天冬氨酸转氨酶(AST)和丙氨酸转氨酶(ALT)的水平。
强效人PPARα激动剂。用于研究人细胞中PPARα受体的生物学。
Legal Information
根据GlaxoSmithKline协议，仅为研究目的出售
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Shinya Okishio et al.
Scientific reports, 10(1), 19578-19578 (2020-11-13)
We explored the beneficial effects of GW7647, a peroxisome proliferator activated receptor α (PPARα) agonist, and metformin, an anti-diabetic drug on an advanced nonalcoholic steatohepatitis (NASH) model in rodents and investigated the possible mechanisms involved. Mice were fed control chow
Yanjie Cheng et al.
Molecular therapy. Nucleic acids, 9, 195-206 (2017-12-17)
Widely varied compounds, including certain plasticizers, hypolipidemic drugs (e.g., ciprofibrate, fenofibrate, WY-14643, and clofibrate), agrochemicals, and environmental pollutants, are peroxisome proliferators (PPs). Appropriate dose of PPs causes a moderate increase in the number and size of peroxisomes and the expression
Sriram Ramanan et al.
Free radical biology & medicine, 45(12), 1695-1704 (2008-10-15)
Whole-brain irradiation (WBI) can lead to cognitive impairment several months to years after irradiation. Studies on rodents have shown a rapid and sustained increase in activated microglia (brain macrophages) following brain irradiation, contributing to a chronic inflammatory response and a
Jun Zhang et al.
Oncotarget, 8(13), 20766-20783 (2017-02-12)
Peroxisome proliferators-activated receptors (PPARα, γ and δ) are potentially effective targets for Type 2 diabetes mellitus therapy. The severe effects of known glitazones and the successfully approved agents (saroglitazar and lobeglitazone) motivated us to study novelly potent PPARs drugs with
Lukas Bahati Tanner et al.
Journal of lipid research, 55(7), 1357-1365 (2014-05-29)
Influenza virus acquires a host-derived lipid envelope during budding, yet a convergent view on the role of host lipid metabolism during infection is lacking. Using a mass spectrometry-based lipidomics approach, we provide a systems-scale perspective on membrane lipid dynamics of
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