G8048
GLP-1R 激动剂
≥98% (HPLC), powder, glucose homeostasis regulator
别名:
2-喹喔啉胺，6,7-二氯-N-（1,1-二甲基乙基）-3-（甲磺酰基）-, 6,7-二氯-2-甲磺酰基-3-N-叔丁基氨基喹喔啉 (DMB), 化合物 2
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关于此项目
经验公式（希尔记法）:
C13H15Cl2N3O2S
化学文摘社编号:
分子量:
348.25
MDL number:
UNSPSC Code:
12352200
NACRES:
NA.77
产品名称
GLP-1R 激动剂, ≥98% (HPLC)
SMILES string
[S](=O)(=O)(C)c1nc2c(nc1NC(C)(C)C)cc(c(c2)Cl)Cl
InChI
1S/C13H15Cl2N3O2S/c1-13(2,3)18-11-12(21(4,19)20)17-10-6-8(15)7(14)5-9(10)16-11/h5-6H,1-4H3,(H,16,18)
InChI key
GNZCSGYHILBXLL-UHFFFAOYSA-N
assay
≥98% (HPLC)
form
powder
storage condition
desiccated
color
light brown-yellow
solubility
DMSO: ≥10 mg/mL
storage temp.
2-8°C
Quality Level
Biochem/physiol Actions
GLP-1R 是一种小分子 GLP-1 受体激动剂。
GLP-1R 是一种小分子 GLP-1 受体激动剂。GLP-1 受体信号转导是调节葡萄糖稳态的主要机制。该化合物代表了一种独特的非肽类工具，用于研究 GLP-1 在体内和体外糖尿病和肥胖模型中的作用。
General description
胰高血糖素样肽-1 受体 (GLP-1R) 激动剂是糖尿病患者调节胰高血糖素样肽 (GLP)-1 的潜在口服药物。GLP-1R 激动剂在降低糖化血红蛋白水平中起关键作用。改善血糖控制和维持体重。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
GLP-1 receptor agonists: a review of head-to-head clinical studies.
Trujillo JM, et al.
Therapeutic advances in endocrinology and metabolism, 6(1), 19-28 (2015)
Long-acting glucagon-like peptide 1 receptor agonists: a review of their efficacy and tolerability.
Garber AJ.
Diabetes Care, 34(Supplement 2), S279-S284 (2011)
Juliana de F Germano et al.
Scientific reports, 10(1), 8284-8284 (2020-05-20)
Given that adverse remodeling is the leading cause of heart failure and death in the USA, there is an urgent unmet need to develop new methods in dealing with this devastating disease. Here we evaluated the efficacy of a short-course
Small-molecule agonists for the glucagon-like peptide 1 receptor.
Knudsen LB, et al.
Proceedings of the National Academy of Sciences of the USA, 104(3), 937-942 (2007)
Juliana de Freitas Germano et al.
International journal of molecular sciences, 22(16) (2021-08-28)
Cardiovascular disease is the main cause of death worldwide, making it crucial to search for new therapies to mitigate major adverse cardiac events (MACEs) after a cardiac ischemic episode. Drugs in the class of the glucagon-like peptide-1 receptor agonists (GLP1Ra)
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