G8173
GW833972A
≥98% (HPLC), powder
别名:
2-[(3-chlorophenyl)amino]-N-(4-pyridinylmethyl)-4-(trifluoromethyl)-5-Pyrimidinecarboxamide hydrochloride
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关于此项目
经验公式（希尔记法）:
C18H13ClF3N5O · HCl
化学文摘社编号:
分子量:
444.24
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
产品名称
GW833972A, ≥98% (HPLC), powder
InChI key
UBHSVFAUAKIVKL-UHFFFAOYSA-N
SMILES string
Cl.FC(F)(F)c1nc(Nc2cccc(Cl)c2)ncc1C(=O)NCc3ccncc3
InChI
1S/C18H13ClF3N5O.ClH/c19-12-2-1-3-13(8-12)26-17-25-10-14(15(27-17)18(20,21)22)16(28)24-9-11-4-6-23-7-5-11;/h1-8,10H,9H2,(H,24,28)(H,25,26,27);1H
assay
≥98% (HPLC)
form
powder
drug control
regulated under CDSA - not available from Sigma-Aldrich Canada
storage condition
desiccated
color
off-white to light brown
solubility
DMSO: ≥20 mg/mL
storage temp.
2-8°C
Quality Level
Application
GW833972A, a selective CB2 cannabinoid receptor agonist, may be used separately or in comparison to other cannabinoid receptor agonist and antagonists to differentiate and characterize the CB2 cannabinoid receptor. GW833972A may be used to help verify that an observed physiological response is cannabinoid receptor CB2-dependent.
Biochem/physiol Actions
GW833972A is a CB2 cannabinoid receptor agonist with 1000-fold selectivity relative to CB1.
GW833972A is a CB2 cannabinoid receptor agonist with 1000-fold selectivity relative to CB1. It is, however, 15-fold less potent than HU210 for CB2 (Ki 7.8 vs. 0.52 nM). The antitumor compound oxaliplatin induces marked hypersensitivity to cold, heat, and chemical pain stimuli (to the point where oxaliplatin therapy has to be discontinued). The hyperalgesia effect is almost completely blocked by pretreatment with GW833972A.
GW833972A is a CB2 receptor agonist with 1000-fold selectivity relative to CB1.
The compound was used to determine the role of CB2 in airway sensory nerve function.
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 3 Oral - Aquatic Chronic 4 - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
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