产品名称
抗 组蛋白去乙酰化酶 4 (HDAC4) 抗体，小鼠单克隆, clone HDAC4-144, purified from hybridoma cell culture
biological source
mouse
conjugate
unconjugated
antibody form
purified from hybridoma cell culture
antibody product type
primary antibodies
clone
HDAC4-144, monoclonal
form
buffered aqueous solution
mol wt
antigen ~140 kDa
species reactivity
human, rat, mouse
enhanced validation
independent
Learn more about Antibody Enhanced Validation
concentration
~2 mg/mL
technique(s)
immunocytochemistry: suitable
immunoprecipitation (IP): suitable
western blot: 1-2 μg/mL using total cell extracts of NIH3T3 fibroblasts cells
isotype
IgG2a
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... HDAC4(9759)
mouse ... Hdac4(208727)
rat ... Hdac4(363287)
Application
小鼠单克隆抗组蛋白脱乙酰化酶4（HDAC4）已被用于：
- 酶联免疫吸附测定（ELISA）
- 免疫印迹
- 免疫细胞化学
- 免疫沉淀
Biochem/physiol Actions
组蛋白脱乙酰化酶（HDAC）催化组蛋白的脱乙酰作用。HDAC4与转录抑制有关。它通过其入核转运和出核转运信号在细胞核和细胞质之间动态迁移。HDAC4与14-3-3和肌细胞增强因子2（Mef2）蛋白质的相互作用干扰了这种穿梭，因此分别将HDAC4导入细胞质和细胞核。
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
General description
单克隆抗组蛋白脱乙酰化酶4（HDAC4）（小鼠IgG2a同种型）来源于HDAC4-144 杂交瘤，该杂交瘤是由小鼠骨髓瘤细胞（NS1）和以对应于C末端添加赖氨酸并与KLH结合的人HDAC4氨基酸的合成肽免疫的BALB / c小鼠脾细胞融合而产生的。HDAC4属于II类哺乳动物HDAC。
Physical form
0.01M 磷酸缓冲盐溶液，pH 7.4，含 15mM 叠氮化钠。
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存储类别
10 - Combustible liquids
wgk
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
此项目有
Erasers of Histone Acetylation: The Histone Deacetylase Enzymes
Seto E, et al.
Cold Spring Harbor Perspectives in Biology, 6 (2014)
Histone deacetylase 4 possesses intrinsic nuclear import and export signals
Wang AH, et al.
Molecular and Cellular Biology, 21, 5992-6005 (2001)
Toon Verheyen et al.
Nucleic acids research, 43(12), 5771-5784 (2015-05-21)
Protein phosphatase-1 (PP1) is a key regulator of transcription and is targeted to promoter regions via associated proteins. However, the chromatin binding sites of PP1 have never been studied in a systematic and genome-wide manner. Methylation-based DamID profiling in HeLa
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