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H1637

顺式-4-羟基-L-脯氨酸

Name: 顺式-4-羟基-<SC>L</SC>-脯氨酸
Brand: SIGMA

collagen synthesis inhibitor

别名:

(2S,4S)-(-)-4-羟基-2-吡咯烷羧酸, CHP

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关于此项目

经验公式（希尔记法）:

C₅H₉NO₃

化学文摘社编号:

618-27-9

分子量:

131.13

NACRES:

NA.26

PubChem Substance ID:

24895470

eCl@ss:

32160406

UNSPSC Code:

12352209

EC Number:

210-542-1

MDL number:

MFCD00064319

Beilstein/REAXYS Number:

81440

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属性

Quality Level

100

assay

≥98% (TLC)

form

powder

technique(s)

ligand binding assay: suitable

color

white to faint yellow

mp

257 °C (dec.) (lit.)

application(s)

peptide synthesis

SMILES string

O[C@@H]1CN[C@@H](C1)C(O)=O

InChI

1S/C5H9NO3/c7-3-1-4(5(8)9)6-2-3/h3-4,6-7H,1-2H2,(H,8,9)/t3-,4-/m0/s1

InChI key

PMMYEEVYMWASQN-IMJSIDKUSA-N

说明

Application

顺式-4-羟基-L-脯氨酸（CHP）是一种可抑制胶原蛋白的合成并已被用作抗癌化合物的脯氨酸类似物。CHP阻断了C2C12鼠骨骼肌细胞中肌管的形成和肌节肌球蛋白重链的表达。CHP抑制了鼠Panc02胰腺癌细胞系和大鼠胰腺癌细胞DSL6A的增殖。

Biochem/physiol Actions

顺式-4-羟基-L-脯氨酸（CHP）及其衍生物可能具有抗癌活性。顺式-4-羟基-L-脯氨酸和其他羟基-L-脯氨酸是潜在药物手性合成的重要中间体。

Other Notes

鹅膏肽毒素而非如胶原蛋白等动物蛋白的组成成分。

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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cis-Hydroxyproline-mediated pancreatic carcinoma growth inhibition in mice.

Dietrich Sturm et al.

International journal of colorectal disease, 25(8), 921-929 (2010-04-21)

This study addressed the question of whether the collagen metabolism modulator cis-4-Hydroxy-L-proline (CHP) is applicable for potential use as a therapeutic inhibitor of pancreatic carcinoma cell growth. Cell proliferation, as well as quantification of apoptosis of murine Panc02 cells, was

Cis-hydroxyproline-induced inhibition of pancreatic cancer cell growth is mediated by endoplasmic reticulum stress.

Christoph Mueller et al.

World journal of gastroenterology, 12(10), 1569-1576 (2006-03-30)

To investigate the biological effects of cis-hydroxyproline (CHP) on the rat pancreatic carcinoma cell line DSL6A, and to examine the underlying molecular mechanisms. The effect of CHP on DSL6A cell proliferation was assessed by using BrdU incorporation. The expression of

Anticancer drug cis-4-hydroxy-L-proline: Correlation of preclinical toxicology with clinical parameters of liver function.

Heather Dickens et al.

Molecular medicine reports, 1(4), 459-464 (2008-07-01)

cis-4-Hydroxy-L-proline (CHP) is being clinically evaluated as an anticancer drug. Since this compound targets the production of L-proline-rich proteins and critical L-proline residues, its impact on long-term cultures of human hepatocytes and toxicity in rats was studied to investigate possible

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全球贸易项目编号

货号	GTIN
H1637-250MG	04061832416472
H1637-1G	04061826059722
H1637-50MG	04061833672693