H5912
抗 磷酸化组蛋白 H2AX (pSer 139 ) 兔抗
IgG fraction of antiserum, buffered aqueous solution
别名:
抗 H2AXS139p
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关于此项目
Conjugate:
unconjugated
Clone:
polyclonal
Application:
microarray
western blot
western blot
Species reactivity:
mouse, human
Citations:
25
Technique(s):
microarray: suitable
western blot: 1:1,000 using whole cell extracts of HeLa (human epitheloid carcinoma) cells or NIH3T3 mouse fibroblast cells treated with staurosporine
western blot: 1:1,000 using whole cell extracts of HeLa (human epitheloid carcinoma) cells or NIH3T3 mouse fibroblast cells treated with staurosporine
Uniprot accession no.:
产品名称
抗 磷酸化组蛋白 H2AX (pSer 139 ) 兔抗, IgG fraction of antiserum, buffered aqueous solution
biological source
rabbit
conjugate
unconjugated
antibody form
IgG fraction of antiserum
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen 15 kDa
species reactivity
mouse, human
technique(s)
microarray: suitable
western blot: 1:1,000 using whole cell extracts of HeLa (human epitheloid carcinoma) cells or NIH3T3 mouse fibroblast cells treated with staurosporine
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
phosphorylation (pSer139)
Quality Level
Gene Information
human ... H2AFX(3014)
mouse ... H2afx(15270)
Application
兔生产的抗磷酸组蛋白H2AX（pSer139）抗体可用于免疫荧光和免疫印迹。
Biochem/physiol Actions
H2AX对于促进特定DNA修复复合物在受损DNA上的组装至关重要。共济失调毛细血管扩张突变（ATM）是参与DNA双链断裂导致的H2AX磷酸化的主要激酶。H2AX基因敲除小鼠对辐射敏感，并且生长迟缓。它们也具有免疫缺陷，突变的雄性不育。
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
General description
H2AX占人类细胞中总H2A补体的2-25％，而在发芽酵母中，它实际上构成了所有H2A分子。它具有N末端和C末端区域，以及中心球状结构域。C末端区域有修饰位点，包括乙酰化、生物素化和磷酸化位点。
Immunogen
与人组蛋白 H2AX (pSer 139 ) 相应的 C 端（氨基酸 134-142）相对应的合成磷酸化肽。
合成肽序列与 KLH 偶联。免疫原序列在小鼠组蛋白 H2AX 中高度保守（单个氨基酸替换）。
Physical form
0.01M 磷酸缓冲盐溶液，pH 7.4，含 15mM 叠氮化钠。
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存储类别
10 - Combustible liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
此项目有
ATM-dependent DNA damage-independent mitotic phosphorylation of H2AX in normally growing mammalian cells
McManus KJ and Hendzel MJ
Molecular Biology of the Cell, 16(10), 5013-5025 (2005)
Kalyan Mahapatra et al.
Scientific reports, 11(1), 11659-11659 (2021-06-04)
As like in mammalian system, the DNA damage responsive cell cycle checkpoint functions play crucial role for maintenance of genome stability in plants through repairing of damages in DNA and induction of programmed cell death or endoreduplication by extensive regulation
Genomic instability in mice lacking histone H2AX
Celeste A, et al.
Science (New York, N.Y.), 296(5569), 922-927 (2002)
H2AX: functional roles and potential applications
Dickey J, et al.
Chromosoma, 118(6), 683-692 (2009)
Resveratrol decreases Rad51 expression and sensitizes cisplatin-resistant MCF-7 breast cancer cells
Leon-Galicia I, et al.
Oncology Reports, 39(6), 3025-3033 (2018)
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