H6503
L-同型半胱氨酸硫内酯 盐酸盐
≥98% (TLC)
别名:
L-2-氨基-4-巯基丁酸 1,4-硫代内酯 盐酸盐
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关于此项目
经验公式（希尔记法）:
C4H7NOS · HCl
化学文摘社编号:
分子量:
153.63
Beilstein:
3911455
EC 号:
MDL编号:
UNSPSC代码:
12352209
eCl@ss:
32160406
PubChem化学物质编号:
NACRES:
NA.26
产品名称
L-同型半胱氨酸硫内酯 盐酸盐, ≥98% (TLC)
质量水平
方案
≥98% (TLC)
表单
powder
颜色
white
mp
185 °C
应用
detection
peptide synthesis
SMILES字符串
Cl[H].N[C@H]1CCSC1=O
InChI
1S/C4H7NOS.ClH/c5-3-1-2-7-4(3)6;/h3H,1-2,5H2;1H/t3-;/m0./s1
InChI key
ZSEGSUBKDDEALH-DFWYDOINSA-N
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应用
- Effects of DL-homocysteine thiolactone on cardiac contractility, coronary flow, and oxidative stress markers in the isolated rat heart：研究DL-同型半胱氨酸硫内酯对心脏功能的作用，揭示它的心血管研究用途和治疗潜力(Zivkovic et al., 2013)。
- Homocysteine is a novel risk factor for suboptimal response of blood platelets to acetylsalicylic acid in coronary artery disease：研究L-同型半胱氨酸硫内酯如何影响冠心病治疗中的血小板反应，说明它的心血管治疗意义(Karolczak et al., 2013)。
生化/生理作用
同型半胱氨酸硫代内酯是一种胺反应剂，被用于研究蛋白质翻译后修饰，尤其是赖氨酸残基的修饰。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
Derrick L Sauls et al.
Thrombosis research, 127(6), 576-581 (2011-02-15)
We have shown that homocysteinemic rabbits have altered fibrinogen that forms fibrin clots with increased resistance to fibrinolysis. Homocysteine thiolactone is a metabolite of homocysteine (Hcys) that can react with amines and introduce a new sulfhydryl group into proteins. Recent
Shima Jalili et al.
The protein journal, 30(5), 299-307 (2011-05-17)
Homocysteine thiolactone (HCTL) is a cyclic thioester of homocysteine, showing high reactivity toward lysine residues of proteins. In the present study the structural properties and aggregation propensity of bovine pancreatic insulin were studied in the presences of increasing concentration of
Homocysteine and its thiolactone-mediated modification of fibrinogen affect blood platelet adhesion.
Joanna Malinowska et al.
Platelets, 23(5), 409-412 (2011-10-21)
Homocysteine (Hcys) and homocysteine thiolactone (HTL) concentrations in organism are correlated with a number of serious pathologies. In the literature, there are few papers describing studies on the effects of homocysteine on proteins that participate in blood coagulation and fibrinolysis
A Rašić-Marković et al.
Acta physiologica Hungarica, 98(1), 17-26 (2011-03-11)
The aim of our study was to investigate the effects of ifenprodil and MK-801 on D,L-homocysteine thiolactone induced seizures in adult rats.Male Wistar rats were divided into following groups: 1. Saline-treated (C, n=10); 2. D,L-homocysteine thiolactone 8 mmol/kg, i.p. (H
Han-Hsin Chang et al.
Molecular vision, 17, 1946-1956 (2011-08-19)
Hyperhomocysteinemia is known to cause degeneration of retinal ganglion cells, but its influence on photoreceptors remains largely unknown. In particular, the role of homocysteine-thiolactone (Hcy-T)--the physiologic metabolite of homocysteine that has been proven to be more cytotoxic than homocysteine itself--as
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