H7125
组胺
≥97% (TLC), powder, H₁ and H₂ histamine receptor agonist
别名:
2-(4-咪唑基)乙胺
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关于此项目
经验公式（希尔记法）:
C5H9N3
化学文摘社编号:
分子量:
111.15
Beilstein:
2012
EC 号:
MDL编号:
UNSPSC代码:
12352116
eCl@ss:
32160406
PubChem化学物质编号:
NACRES:
NA.77
产品名称
组胺, ≥97.0%
质量水平
方案
≥97.0%
沸点
167 °C/0.8 mmHg (lit.)
mp
83-84 °C (lit.)
储存温度
−20°C
SMILES字符串
NCCc1c[nH]cn1
InChI
1S/C5H9N3/c6-2-1-5-3-7-4-8-5/h3-4H,1-2,6H2,(H,7,8)
InChI key
NTYJJOPFIAHURM-UHFFFAOYSA-N
基因信息
human ... CA1(759), CA2(760), HRH1(3269), HRH2(3274), HRH3(11255), HRH4(59340)
rat ... Hrh1(24448), Hrh3(85268)
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一般描述
组胺是由下丘脑后部神经元产生的神经递质。大脑中，组胺主要存在于灰质部分。
应用
组胺用于：
- 刺激调节型细胞分泌
- 在反应混合物中，活化血液，通过荧光测定法测定凝血酶（因子iia）活性
- 填充腔室腔侧，研究其对TJ相关屏障的影响以及声带上皮中TJ（紧密连接）标志物的表达
生化/生理作用
内源性 H1 和 H2 组胺受体激动剂；H1 的活化可以使 Ca2+ 移动；H2 的活化可促进神经元中腺苷酸环化酶的活性；活化一氧化氮合成酶；有效的血管舒张剂。
内源性 H1 和 H2 组胺受体激动剂；可活化一氧化氮合成酶；有效的血管舒张剂。
组胺参与先天免疫应答和获得性免疫应答，介导过敏和炎症。有助于肠道肌肉收缩。在过敏性休克过程中，组胺引起支气管收缩。组胺还参与分泌胃酸、控制上皮和内皮屏障。
警示用语：
Danger
危险分类
Acute Tox. 3 Oral - Eye Irrit. 2 - Resp. Sens. 1 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3
靶器官
Respiratory system
储存分类代码
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
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