H7125
组胺
≥97% (TLC), powder, H₁ and H₂ histamine receptor agonist
别名:
2-(4-咪唑基)乙胺
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关于此项目
经验公式（希尔记法）:
C5H9N3
化学文摘社编号:
分子量:
111.15
NACRES:
NA.77
PubChem Substance ID:
eCl@ss:
32160406
UNSPSC Code:
12352116
EC Number:
200-100-6
MDL number:
Beilstein/REAXYS Number:
2012
产品名称
组胺, ≥97.0%
InChI key
NTYJJOPFIAHURM-UHFFFAOYSA-N
InChI
1S/C5H9N3/c6-2-1-5-3-7-4-8-5/h3-4H,1-2,6H2,(H,7,8)
SMILES string
NCCc1c[nH]cn1
assay
≥97.0%
bp
167 °C/0.8 mmHg (lit.)
mp
83-84 °C (lit.)
storage temp.
−20°C
Quality Level
Gene Information
human ... CA1(759), CA2(760), HRH1(3269), HRH2(3274), HRH3(11255), HRH4(59340)
rat ... Hrh1(24448), Hrh3(85268)
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Application
组胺用于：
- 刺激调节型细胞分泌
- 在反应混合物中，活化血液，通过荧光测定法测定凝血酶（因子iia）活性
- 填充腔室腔侧，研究其对TJ相关屏障的影响以及声带上皮中TJ（紧密连接）标志物的表达
Biochem/physiol Actions
内源性 H1 和 H2 组胺受体激动剂；H1 的活化可以使 Ca2+ 移动；H2 的活化可促进神经元中腺苷酸环化酶的活性；活化一氧化氮合成酶；有效的血管舒张剂。
内源性 H1 和 H2 组胺受体激动剂；可活化一氧化氮合成酶；有效的血管舒张剂。
组胺参与先天免疫应答和获得性免疫应答，介导过敏和炎症。有助于肠道肌肉收缩。在过敏性休克过程中，组胺引起支气管收缩。组胺还参与分泌胃酸、控制上皮和内皮屏障。
General description
组胺是由下丘脑后部神经元产生的神经递质。大脑中，组胺主要存在于灰质部分。
signalword
Danger
Hazard Classifications
Acute Tox. 3 Oral - Eye Irrit. 2 - Resp. Sens. 1 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3
target_organs
Respiratory system
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
Histamine in the nervous system
Haas HL, et al.
Physiological Reviews, 88(3), 1183-1241 (2008)
Maikel Wijtmans et al.
Journal of medicinal chemistry, 54(6), 1693-1703 (2011-02-26)
The histamine H(3) (H(3)R) and H(4) (H(4)R) receptors attract considerable interest from the medicinal chemistry community. Given their relatively high homology yet widely differing therapeutic promises, ligand selectivity for the two receptors is crucial. We interrogated H(4)R/H(3)R selectivities using ligands
Surfactants attenuate gas embolism-induced thrombin production
Eckmann DM and Diamond SL
Anesthesiology, 100(1), 77-84 (2004)
Endogenous histamine facilitates long-term potentiation in the hippocampus during walking
Luo T and Leung LS
The Journal of Neuroscience, 30(23), 7845-7852 (2010)
Tight junction-related barrier contributes to the electrophysiological asymmetry across vocal fold epithelium
Zhang Q and Fisher K
PLoS ONE, 7(3), e34017-e34017 (2012)
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