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H9523

3-(2-氨乙酸)吲哚盐酸盐

Name: 3-(2-氨乙酸)吲哚 盐酸盐
Brand: SIGMA

≥98%, powder, neurotransmitter

别名:

3-(2-氨基乙基)-5 -羟基吲哚盐酸盐, 5-羟色胺, 5-羟色胺盐酸盐

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关于此项目

经验公式（希尔记法）:

C₁₀H₁₂N₂O · HCl

化学文摘社编号:

153-98-0

分子量:

212.68

NACRES:

NA.77

PubChem Substance ID:

24278124

UNSPSC Code:

12352200

MDL number:

MFCD00012686

Beilstein/REAXYS Number:

3570963

Assay:

≥98%

Form:

powder

Quality level:

200

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产品名称

3-(2-氨乙酸)吲哚盐酸盐, powder

description

Drug Control: Kábítószer / Narcotic Drug (Hungary), 78/2022. (XII. 28.) BM rendelet

Quality Level

200

assay

≥98%

form

powder

drug control

Kábítószer / Narcotic Drug (Hungary), 78/2022. (XII. 28.) BM rendelet

color

white to off-white

mp

149-154 °C (lit.)

solubility

H₂O: 17 mg/mL, 0.1 M HCl: 22 mg/mL, ethanol: 5.3 mg/mL

storage temp.

2-8°C

SMILES string

Cl[H].NCCc1c[nH]c2ccc(O)cc12

InChI

1S/C10H12N2O.ClH/c11-4-3-7-6-12-10-2-1-8(13)5-9(7)10;/h1-2,5-6,12-13H,3-4,11H2;1H

InChI key

MDIGAZPGKJFIAH-UHFFFAOYSA-N

Gene Information

human ... HTR3A(3359)

General description

血清素普遍存在于所有动物中。它在中枢和外周神经系统中(CAN/PNS)发挥多样功能，是一种激素和丝裂原分子，血清素由大脑中的轴突终末生产。动作电位引发血清素释放，在突触中扩散结合到突触后受体引起神经反应。血清素在发育、呼吸、体温调节、内分泌、心血管和胃肠道功能中起重要作用。还在睡眠觉醒周期、性、情绪、记忆、攻击性、痛觉、学习和认知等感知觉行为中发挥作用。血清素影响多种精神障碍，包括精神分裂、神经性厌食症、抑郁，还影响强迫症、惊恐发作和社交恐惧症等焦虑障碍。血清素水平变化与药物滥用、赌博、注意力缺陷障碍、强迫症和冲动性的冲动相关障碍或人格障碍有关。

Application

盐酸血清素用于：研究5-羟色胺受体拮抗剂调节肝脏球状体纤维化的机制，研究其对人胚胎肾脏细胞细胞外信号调节激酶(ERK)磷酸化的影响，用于结肠癌细胞系的transwell试验、愈伤试验和肿瘤同种异体移植试验

Biochem/physiol Actions

神经递质。

Features and Benefits

该化合物收录于受体分类和信号转导手册的《生物胺转运体》页面。想要浏览手册的其他页面，请单击此处。

Preparation Note

溶液需新鲜配制。

pictograms

GHS06,GHS08

signalword

Danger

hcodes

H301,H361

pcodes

P202 - P264 - P280 - P301 + P310 - P405 - P501

Hazard Classifications

Acute Tox. 3 Oral - Repr. 2

存储类别

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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The Onset and Progression of Chronic Colitis Parallels Increased Mucosal Serotonin Release via Enterochromaffin Cell Hyperplasia and Downregulation of the Serotonin Reuptake Transporter.

Rhian Stavely et al.

Inflammatory bowel diseases, 24(5), 1021-1034 (2018-04-19)

Serotonin (5-hydroxytryptamine, 5-HT) has been linked with several inflammation-associated intestinal diseases, including ulcerative colitis (UC). The largest pool of 5-HT in the body is in enterochromaffin (EC) cells located throughout the intestinal tract. EC cells are mechanosensitive and detect noxious

Serotonin: a review.

L F Mohammad-Zadeh et al.

Journal of veterinary pharmacology and therapeutics, 31(3), 187-199 (2008-05-13)

5-Hydroxytryptamine, or serotonin, is a biogenic amine most noted for its role as a neurotransmitter. Manipulation of serotonin in animal models was used as a tool for studying its role in humans. Through such research serotonin has been shown to

Mechanisms of 5-HT receptor antagonists in the regulation of fibrosis in a 3D human liver spheroid model.

Sara Redenšek Trampuž et al.

Scientific reports, 14(1), 1396-1396 (2024-01-17)

Non-alcoholic steatohepatitis (NASH) is a major health problem leading to liver fibrosis and hepatocellular carcinoma, among other diseases, and for which there is still no approved drug treatment. Previous studies in animal models and in LX-2 cells have indicated a

Effect of social isolation on anxiety-related behaviors, cortisol, and monoamines in adult zebrafish.

Soaleha Shams et al.

Behavioral neuroscience, 131(6), 492-504 (2017-12-01)

Social isolation can be used to study behavioral, neural, and hormonal mechanisms that regulate interactions in social animals. Although isolation effects have been reported in social mammals and various fish species, systematic studies with isolated zebrafish are rare. Here, the

Serotonin Receptors

Nichols David E and Nichols Charles D.

Chemical Reviews (2008)

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商品

Serotonin Synthesis & Metabolism

Serotonin is stored in cells and metabolized by MAO, influencing CNS, GI, and platelet functions.

血清素合成及代谢

血清素（5-羟色胺）主要存在于三种主要细胞类型中：i）中杻神经系统（CNS）和肠肌间神经丛中的血清素能神经元，ii）胃肠道粘膜中的肠嗜铬细胞，和iii）血小板。血清素的代谢主要通过外部线粒体膜酶单胺氧化酶（MAO）进行，它以两种分子亚型存在，分别称为MAO-A和MAO-B。

全球贸易项目编号

货号	GTIN
H9523-25MG	04061835253371
H9523-1G	04061835253357
H9523-100MG	04061835253340
H9523-250MG	04061835253364

我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.

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