H9539

抗 HMGB1 (HMG1)（C 端）兔抗

Name: 抗 HMGB1 (HMG1)（C 端） 兔抗
Brand: SIGMA

affinity isolated antibody, buffered aqueous solution

别名:

抗两性蛋白, 抗高迁移率族蛋白 1, 抗高迁移率族蛋白 b1

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关于此项目

UNSPSC Code:

12352203

NACRES:

NA.41

MDL number:

MFCD02263062

Conjugate:

unconjugated

Clone:

polyclonal

Application:

immunoprecipitation (IP)
indirect immunofluorescence
western blot

Species reactivity:

rat, mouse, human

Citations:

Technique(s):

immunoprecipitation (IP): 5-10 μg using HEK-293T cell lysates.
indirect immunofluorescence: suitable
western blot: 0.5-1 μg/mL using 3T3 or PC12 cell lysates.

Uniprot accession no.:

P09429

主要文件

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产品名称

抗 HMGB1 (HMG1)（C 端）兔抗, affinity isolated antibody, buffered aqueous solution

biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen 25 kDa

species reactivity

rat, mouse, human

packaging

antibody small pack of 25 μL

enhanced validation

independent
Learn more about Antibody Enhanced Validation

technique(s)

immunoprecipitation (IP): 5-10 μg using HEK-293T cell lysates.
indirect immunofluorescence: suitable
western blot: 0.5-1 μg/mL using 3T3 or PC12 cell lysates.

UniProt accession no.

P09429

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Quality Level

200

Gene Information

human ... HMGB1(3146)
mouse ... Hmgb1(15289)
rat ... Hmgb1(25459)

Application

家兔抗 HMGB1 (HMG1)（C 端）抗体可用于 ELISA 和免疫荧光。

Biochem/physiol Actions

在细胞核中，HMGB1（高迁移率族蛋白B1）充当核小体稳定剂和转录调节剂。它还表现出伴侣样活性并抑制聚谷氨酰胺的聚集。它在炎症和自噬中起一定作用。HMGB1可与Toll样受体（TLR）2和4、白细胞介素-1β、趋化因子（C-X-C基序）配体12（CXCL12）和病原体相关分子模式（PAMP）分子相互作用。它还充当与损伤相关的分子模式分子（DAMP）。

Disclaimer

除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。

General description

高迁移率族(HMG1)由活化的单核细胞和巨噬细胞分泌。该基因定位于人类染色体13q12。

Immunogen

与 KLH 偶联的人 HMGB1 第 165-180 位氨基酸相应的的合成肽。相应的的序列在小鼠和大鼠中是保守的。

Other Notes

顺序使用各种技术和制剂获得最佳结果，我们建议通过滴定法确定最佳工作稀释度。

Physical form

0.01M 磷酸缓冲盐溶液，pH 7.4，含 15mM 叠氮化钠。

Preparation Note

若需连续使用，可在2-8°C下保存最长一个月。
若需延长储存时间，可将溶液分装并冷冻。
不建议反复冻融或储存在“无霜”冰柜中。如果延长储存时间后出现轻微浑浊，则在使用前离心澄清溶液。如果未在 12 小时内使用，工作稀释液应丢弃。

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存储类别

12 - Non Combustible Liquids

wgk

nwg

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

法规信息

常规特殊物品

此项目有

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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在文件库中查找您最近购买产品的文档。

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Complement-mediated Damage to the Glycocalyx Plays a Role in Renal Ischemia-reperfusion Injury in Mice.

Anjan K Bongoni et al.

Transplantation direct, 5(4), e341-e341 (2019-04-18)

Complement activation plays an important role in the pathogenesis of renal ischemia-reperfusion (IR) injury (IRI), but whether this involves damage to the vasculoprotective endothelial glycocalyx is not clear. We investigated the impact of complement activation on glycocalyx integrity and renal

Cardiomyocyte-derived HMGB1 takes a protective role in CVB3-induced viral myocarditis via inhibiting cardiac apoptosis.

Tianle Sun et al.

Immunology and cell biology, 101(8), 735-745 (2023-05-31)

Coxsackievirus B3 (CVB3)-induced viral myocarditis (VMC) is characterized by immune cell infiltration and myocardial damage. High mobility group box 1 (HMGB1) is a highly conserved nuclear DNA-binding protein that participates in DNA replication, transcriptional regulation, repair response and inflammatory response

CircTLK1 modulates sepsis-induced cardiomyocyte apoptosis via enhancing PARP1/HMGB1 axis-mediated mitochondrial DNA damage by sponging miR-17-5p.

Yu Qiu et al.

Journal of cellular and molecular medicine, 25(17), 8244-8260 (2021-08-20)

Septic cardiomyopathy is a common complication of sepsis with high morbidity and mortality, but lacks specific therapy. This study aimed to reveal the role of circTLK1 and its potential mechanisms in septic cardiomyopathy. The in vitro and in vivo models

Quantification of Serum High Mobility Group Box 1 by Liquid Chromatography/High-Resolution Mass Spectrometry: Implications for Its Role in Immunity, Inflammation, and Cancer.

Liwei Weng et al.

Analytical chemistry, 90(12), 7552-7560 (2018-05-24)

High mobility group box 1 (HMGB1) is a non-histone chromosomal protein, which can be secreted through a variety of pathways and bind to pattern recognition receptors to release pro-inflammatory cytokines. Previous studies have suggested that HMGB1 is upregulated in numerous

MiR-142-3p functions as a potential tumor suppressor directly targeting HMGB1 in non-small-cell lung carcinoma.

Xiao P and Liu WL

International Journal of Clinical and Experimental Pathology (2015)

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抗 HMGB1 (HMG1)（C 端） 兔抗

affinity isolated antibody, buffered aqueous solution

选择尺寸

关于此项目

主要文件

属性

产品名称

biological source

conjugate

antibody form

antibody product type

clone

form

mol wt

species reactivity

packaging

enhanced validation

technique(s)

UniProt accession no.

shipped in

storage temp.

target post-translational modification

Quality Level

Gene Information

相关类别

说明

Application

Biochem/physiol Actions

Disclaimer

General description

Immunogen

Other Notes

Physical form

Preparation Note

安全信息

存储类别

wgk

flash_point_f

flash_point_c

ppe

法规信息

文件

分析证书(COA)

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抗 HMGB1 (HMG1)（C 端）兔抗