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Merck
CN

HPA001758

Anti-SOX9 Antibody

Prestige Antibodies® Powered by Atlas Antibodies, rabbit polyclonal

别名:

抗-转录因子SOX-9 兔抗

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关于此项目

UNSPSC Code:
12352203
Human Protein Atlas Number:
HPA001758
NACRES:
NA.41
MDL number:
MFCD03792047

主要文件

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产品名称

抗-SOX9 兔抗, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution

biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

product line

Prestige Antibodies® Powered by Atlas Antibodies

form

buffered aqueous glycerol solution

species reactivity

human

enhanced validation

recombinant expression
orthogonal RNAseq
RNAi knockdown
Learn more about Antibody Enhanced Validation

technique(s)

immunoblotting: 0.04-0.4 μg/mL
immunofluorescence: 0.25-2 μg/mL
immunohistochemistry: 1:500-1:1000

immunogen sequence

SQRTHIKTEQLSPSHYSEQQQHSPQQIAYSPFNLPHYSPSYPPITRSQYDYTDHQNSSSYYSHAAGQGTGLYSTFTYMNPAQRPMYTPIADTSGVPSIPQTHSPQHWEQPVYTQLTR

UniProt accession no.

P48436

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Quality Level

100

Gene Information

human ... SOX9(6662)

相关类别

General description

性别决定区Y框蛋白9（SOX9）基因定位于人类染色体17q24.3。该基因主要在成人组织以及胎儿睾丸和骨骼组织中表达。它由两个功能结构域组成：高迁移率基团（HMG）DNA结合结构域和C端反式激活结构域。

Immunogen

转录因子SOX-9重组蛋白抗原表位标签(PrEST)

Other Notes

相应抗原APREST84775

Physical form

磷酸盐缓冲盐溶液，pH 7.2，含有40%甘油和0.02%叠氮化钠

Legal Information

Prestige Antibodies is a registered trademark of Merck KGaA, Darmstadt, Germany

Application

兔抗 SOX9抗体可用于免疫组化和免疫荧光分析。
兔抗SOX9抗体属Prestige 抗体，经人类蛋白质图谱（HPA）计划开发和验证。每种抗体都通过针对数百种正常和疾病组织的免疫组织化学进行测试。通过单击图像库链接，可以在人类蛋白质图谱（HPA）站点上查看这些图像。还采用免疫荧光和蛋白质印迹法对抗体进行检测。想要查看有关Prestige 抗体和HPA的方案和其他实用信息，请访问 sigma.com/prestige。

Biochem/physiol Actions

SOX9（性决定区Y框蛋白9）是一种转录因子，与睾丸决定因子性别决定区Y（SRY）相关。它在软骨分化和早期睾丸发育中发挥重要作用。据报道，SOX9可能在软骨形成中起作用。人体SOX9基因突变可引起短指发育不良、严重侏儒综合征和常染色体XY性逆转。

Disclaimer

除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。

Features and Benefits

Prestige Antibodies®是经过高度表征和广泛验证的抗体，同时还有一个优点是其每个靶标的所有可用表征数据都可以通过位于此页面顶部产品名称下方的人类蛋白质图谱门户进行访问。Prestige Antibodies®对其他蛋白质的独特性和低交叉反应性是通过严密的抗原区域选择、亲和纯化和严格的选择来实现的。针对每一个Prestige Antibody都存在有对应的Prestige抗原对照，并可在链接区域内找到。

每个Prestige Antibody都是按照以下方法进行测试的：
  • 44例正常人类组织以及20例最常见癌症类型组织的IHC组织阵列。
  • 364个人类重组蛋白片段的蛋白阵列。

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存储类别

10 - Combustible liquids

wgk

WGK 1

ppe

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

法规信息

常规特殊物品
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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
C89924
C43344
B43337
R00717
A08891

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Qi Sun et al.
Oncotarget, 8(36), 60312-60323 (2017-09-28)
The aim of this study was to explore the mechanisms of Hyperbaric oxygen (HBO) protective on interleukin-1β (IL-1β) induced rat's mandibular condylar chondrocytes. Chondrocytes were exposure to Hyperbaric oxygen after induced inflammatory by IL-1β. After that, the expression of p-JNK
Ya-Hui Chen et al.
PloS one, 10(8), e0134327-e0134327 (2015-08-27)
Whether hepatocytes can convert into biliary epithelial cells (BECs) during biliary injury is much debated. To test this concept, we traced the fate of genetically labeled [dipeptidyl peptidase IV (DPPIV)-positive] hepatocytes in hepatocyte transplantation model following acute hepato-biliary injury induced
Loss of DNA-dependent dimerization of the transcription factor SOX9 as a cause for campomelic dysplasia
<BIG>Sock E, et al.</BIG>
Human Molecular Genetics, 12, 1439-1447 (2003)
V Lefebvre et al.
Molecular and cellular biology, 17(4), 2336-2346 (1997-04-01)
The identification of mutations in the SRY-related SOX9 gene in patients with campomelic dysplasia, a severe skeletal malformation syndrome, and the abundant expression of Sox9 in mouse chondroprogenitor cells and fully differentiated chondrocytes during embryonic development have suggested the hypothesis
Constitutive WNT/CTNNB1 activation triggers spermatogonial stem cell proliferation and germ cell depletion
<BIG>Chassot AA, et al.</BIG>
Developmental Biology Journal, 426, 17-27 (2017)
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