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Merck
CN

HPA001888

抗-LRG1 兔抗

Ab1, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution

别名:

抗-LRG 兔抗, 抗-富亮氨酸α-2-糖蛋白前体 兔抗

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关于此项目

UNSPSC Code:
12352203
NACRES:
NA.41
Human Protein Atlas Number:
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产品名称

抗-LRG1 兔抗, Ab1, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution

Quality Level

biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

product line

Prestige Antibodies® Powered by Atlas Antibodies

form

buffered aqueous glycerol solution

species reactivity

human

enhanced validation

orthogonal RNAseq
Learn more about Antibody Enhanced Validation

technique(s)

immunoblotting: 0.04-0.4 μg/mL
immunohistochemistry: 1:200-1:500

immunogen sequence

TLSPKDCQVFRSDHGSSISCQPPAEIPGYLPADTVHLAVEFFNLTHLPANLLQGASKLQELHLSSNGLESLSPEFLRPVPQLRVLDLTRNALTGLPPGLFQASATLDTLVLKENQLEVLEVSWLHGLKALGHLDLSG

UniProt accession no.

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... LRG1(116844)

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Application

由Atlas Antibodies提供技术支持的所有Prestige Antibodies抗体均由人类蛋白质图集(HPA)项目开发和验证,因此受到业内最广泛的表征支持。

人类蛋白质图集项目可以分为三大部分: 人体组织图谱、癌症图谱和人类细胞图谱。在组织和癌症图谱项目支持下产生的抗体已通过对数百种正常和疾病组织的免疫组织化学分析得到了验证,并且通过近期人类细胞图谱项目的努力,许多抗体已经过免疫荧光分析的表征,从而绘制人类蛋白质组图谱,不仅是在组织水平上,现在已经达到亚细胞水平。在人类蛋白质图集项目网站上单击图像库链接,可以查看这些图像和庞大的数据集。我们还提供Prestige Antibodies® 抗体的实验方案和其他有用信息。

Disclaimer

除非我们的产品目录或产品附带的其他公司文档另有说明,否则我们的产品仅供研究使用,不得用于任何其他目的,包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。

Features and Benefits

Prestige抗体®是经过高度表征和广泛验证的抗体,同时还有一个优点是其每个靶标的所有可用表征数据都可以通过位于此页面顶部产品名称下方的人类蛋白质图谱门户进行访问。Prestige抗体对其他蛋白质的独特性和低交叉反应性®是通过严密的抗原区域选择、亲和纯化和严格的选择来实现的。针对每一个Prestige Antibody都存在有对应的Prestige抗原对照,并可在链接区域内找到。

每个Prestige Antibody都是按照以下方法进行测试的:
  • 44例正常人类组织以及20例最常见癌症类型组织的IHC组织阵列。
  • 364个人类重组蛋白片段的蛋白阵列。

General description

钙黏着蛋白17也称为肝肠钙黏着蛋白(LI cadherin),是通常在肝癌、胰腺癌和胃癌中过度表达的一种细胞黏附蛋白

Immunogen

富含亮氨酸α-2-糖蛋白前体重组蛋白表位信号标签(PrEST)

Other Notes

相应抗原APREST84390

Physical form

溶于磷酸盐缓冲盐水,pH 7.2,含有40%甘油和0.02%叠氮化钠

Legal Information

Prestige Antibodies is a registered trademark of Merck KGaA, Darmstadt, Germany

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存储类别

10 - Combustible liquids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

法规信息

常规特殊物品
此项目有

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Ying Zhou et al.
PloS one, 12(4), e0175122-e0175122 (2017-04-05)
Leucine-rich-alpha-2-glycoprotein 1 (LRG1) has been shown to be involved in various human malignancies. Whether it plays a role in colorectal cancer (CRC) development remains unclear. Here, we investigated whether and through what mechanism LRG1 functions in human CRC cells. The
Anabella Srebrow et al.
Journal of cell science, 119(Pt 13), 2635-2641 (2006-06-22)
Alternative splicing is a crucial mechanism for generating protein diversity. Different splice variants of a given protein can display different and even antagonistic biological functions. Therefore, appropriate control of their synthesis is required to assure the complex orchestration of cellular
Lucia Mundo et al.
International journal of molecular sciences, 22(16) (2021-08-28)
Leucine-rich a-2-glycoprotein 1 (LRG1) is a candidate therapeutic target for treating the neovascular form of age-related macular degeneration (nvAMD). In this study we examined the expression of LRG1 in eyes of nvAMD patients. Choroidal neovascular membranes (CNVMs) from patients who
Qian Zhang et al.
OncoTargets and therapy, 11, 2745-2752 (2018-05-23)
Leucine-rich α-2-glycoprotein-1 (LRG1) is differentially expressed in many kinds of diseases including cancer, however, it has not been thoroughly studied yet. The objective of this study was to detect the expression and potential mechanism of LRG1 in colorectal cancer (CRC).
Guo Nan Yin et al.
Experimental & molecular medicine, 54(5), 626-638 (2022-05-14)
Diabetes mellitus (DM) is a chronic metabolic disorder characterized by inappropriate hyperglycemia, which causes endothelial dysfunction and peripheral neuropathy, ultimately leading to multiple complications. One prevalent complication is diabetic erectile dysfunction (ED), which is more severe and more resistant to

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