Anti-LNX1 antibody produced in rabbit

LNX1 (ligand of numb-protein X 1) is the PDZ (PSD95, Dlg1, and zo-1) domain-containing member of the RING (really interesting new gene) finger-type E3 ubiquitin ligase family. It participates in tumorigenesis. It is associated with various signal transduction pathways such as notch pathway. It consists of different protein-protein interaction domains including a RING finger and four PDZ domains.

E3 ubiquitin-protein ligase LNX recombinant protein epitope signature tag (PrEST)

All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project and as a result, are supported by the most extensive characterization in the industry.

The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. We also provide Prestige Antibodies^® protocols and other useful information.

LNX1 (ligand of numb-protein X 1) interacts with the phosphotyrosine-binding (PTB) domain which is essential for NUMB functions i.e. cell cycle control. It helps to cluster PTB-containing proteins along with functionally related transmembrane proteins in specific membrane compartments. In addition, it has been shown that downregulation of LNX1 causes cell cycle arrest in G0/G1 phase by suppression of of β-catenin, MAPK (mitogen activated protein kinase), NF (nuclear factor) κB, c-Myc-dependent pathway and by activation of p53, TGF (transforming growth factor)-β-dependent pathway.

Prestige Antibodies^® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies^® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.

Every Prestige Antibody is tested in the following ways:

• IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues.
• Protein array of 364 human recombinant protein fragments.

Solution in phosphate-buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide

Corresponding Antigen APREST86407

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