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Merck
CN

HPA003575

抗-TRIM22 兔抗

Ab2, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution

别名:

抗-50 kDa刺激的反式作用因子 兔抗, 抗-RING指蛋白94 兔抗, 抗-Staf-50 兔抗, 抗-含三结构域蛋白的蛋白质22 兔抗

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关于此项目

UNSPSC Code:
12352203
NACRES:
NA.41
Human Protein Atlas Number:
HPA003575
Conjugate:
unconjugated
Clone:
polyclonal
Application:
immunoblotting
immunofluorescence
immunohistochemistry
Species reactivity:
human
Citations:
8
Technique(s):
immunoblotting: 0.04-0.4 μg/mL
immunofluorescence: 0.25-2 μg/mL
immunohistochemistry: 1:500-1:1000
Uniprot accession no.:
Q8IYM9

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产品名称

抗-TRIM22 兔抗, Ab2, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution

biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

product line

Prestige Antibodies® Powered by Atlas Antibodies

form

buffered aqueous glycerol solution

species reactivity

human

enhanced validation

RNAi knockdown
Learn more about Antibody Enhanced Validation

technique(s)

immunoblotting: 0.04-0.4 μg/mL
immunofluorescence: 0.25-2 μg/mL
immunohistochemistry: 1:500-1:1000

immunogen sequence

NEVVKECQEKLQVALQRLIKEDQEAEKLEDDIRQERTAWKNYIQIERQKILKGFNEMRVILDNEEQRELQKLEEGEVNVLDNLAAATDQLVQQRQDASTLISDLQRRLRGSSVEMLQDVIDVMKRSESWTLKKPKSVSKKLKSVFRV

UniProt accession no.

Q8IYM9

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Quality Level

100

Gene Information

human ... TRIM22(10346)

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Disclaimer

除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、体外或体内治疗用途，或人类或动物任何类型的消费或使用。

Application

成功使用该抗体的应用以及相关的同行评审论文如下所示。
蛋白质免疫印迹分析（1篇论文）

Biochem/physiol Actions

三结构域蛋白22（tripartite motif-containing 22）是一种由人TRIM22基因编码的蛋白质，属于三结构域（tripartite motif ，TRIM）蛋白超家族。该家族的成员是针对病毒感染胡先天性免疫应答的重要效应因子。它是应干扰素（IFN）诱导蛋白，也是p53靶基因。它通过限制病毒复制在病毒防御中起作用，并可作为泛素E3连接酶。该基因对于RNA 病毒（如乙肝病毒（HBV）、脑心肌炎病毒（ECMV）和人免疫缺陷病毒1型（HIV-1））具有抗病毒活性。它参与 NF-κB的活化。它可作为NF-κB介导的转录的正向调节剂。

Features and Benefits

Prestige抗体®是经过高度表征和广泛验证的抗体，同时还有一个优点是其每个靶标的所有可用表征数据都可以通过位于此页面顶部产品名称下方的人类蛋白质图谱门户进行访问。Prestige抗体对其他蛋白质的独特性和低交叉反应性®是通过严密的抗原区域选择、亲和纯化和严格的选择来实现的。针对每一个Prestige 抗体都存在有对应的Prestige抗原对照，并可在链接区域内找到。

每个Prestige 抗体都是按照以下方法进行测试的：
  • 44例正常人类组织以及20例最常见癌症类型组织的IHC组织阵列。
  • 364个人类重组蛋白片段的蛋白阵列。

Immunogen

三结构域蛋白22重组蛋白质表位信号标签（PrEST）

Other Notes

相应抗原APREST86655

Physical form

溶于磷酸盐缓冲盐水，pH 7.2，含有40%甘油和0.02%叠氮化钠

Legal Information

Prestige Antibodies is a registered trademark of Merck KGaA, Darmstadt, Germany

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存储类别

10 - Combustible liquids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

法规信息

常规特殊物品
此项目有

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
A11983
R04091
R004091

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Hui Tian et al.
Yonsei medical journal, 59(4), 511-518 (2018-05-12)
Hepatitis C virus (HCV) infection is a major cause of liver disease. Several miRNAs have been found to be associated with HCV infection. This study aimed to investigate the functional roles and possible molecular mechanisms of miR-215 in HCV replication.
Ravesh Singh et al.
Journal of virology, 88(8), 4291-4303 (2014-01-31)
The antiviral role of TRIM E3 ligases in vivo is not fully understood. To test the hypothesis that TRIM5α and TRIM22 have differential transcriptional regulation and distinct anti-HIV roles according to infection phase and compartment, we measured TRIM5α, TRIM22, and
Filippo Turrini et al.
Virus research, 269, 197631-197631 (2019-05-29)
The human immunodeficiency virus type-1 (HIV-1) establishes a state of latent infection in a small number of CD4+ T lymphocytes that, nonetheless, represent a major obstacle to viral eradication. We here show that Tripartite Motif-containing protein 22 (TRIM22), an epigenetic
Shanshan Yu et al.
Biochemical and biophysical research communications, 410(2), 247-251 (2011-06-10)
Increasing evidence suggests that TRIM family proteins may play important roles in the regulation of innate immune signaling pathways. Here we report TRIM22 is involved in the activation of NF-κB. It was found that overexpression of TRIM22 could dose-dependently activate
Jessica Petersson et al.
Experimental cell research, 316(4), 568-579 (2009-12-17)
TRIM22 (Staf50), a member of the TRIM protein family, is an interferon (IFN)-inducible protein as well as a p53 target gene. The function of TRIM22 is largely unknown, but TRIM22 is suggested to play a role in viral defense by
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