HPA004114
抗-MRC1 兔抗
Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution
别名:
抗-CD206抗原, 抗-MMR, 抗-巨噬细胞甘露糖受体 1 前体, 抗-C型凝集素结构域家族 13 成员 D
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
product line
Prestige Antibodies® Powered by Atlas Antibodies
form
buffered aqueous glycerol solution
species reactivity
human
enhanced validation
independent
orthogonal RNAseq
Learn more about Antibody Enhanced Validation
technique(s)
immunoblotting: 0.04-0.4 μg/mL, immunohistochemistry: 1:1000-1:2500
immunogen sequence
NEDHKRCVDAVSPSAVQTAACNQDAESQKFRWVSESQIMSVAFKLCLGVPSKTDWVAITLYACDSKSEFQKWECKNDTLLGIKGEDLFFNYGNRQEKNIMLYKGSGLWSRWKIYG
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... MRC1(4360)
General description
甘露糖受体C型1 (MRC1)是一种跨膜糖蛋白，在M2巨噬细胞中高水平表达。该功能性基因有30个外显子，全长101.74 kb。MRC1由1个蓖麻蛋白b型凝集素结构域(RICIN)、1个纤维连接蛋白ii型结构域(FN2)、8个c型凝集素样结构域(CTLD)、1个跨膜结构域(TM)和1个短胞质结构域组成。它也在内皮细胞和质膜上表达。该基因位于人染色体10p12。
Immunogen
巨噬细胞甘露糖受体 1 前体重组蛋白表位信号标签（PrEST）
Application
MRC1抗体还可用于：
- 免疫荧光Ab染色
- 共聚焦显微镜分析
- 免疫组化染色
Biochem/physiol Actions
C 型甘露糖受体1（MRC1）参与吞噬作用。
甘露糖受体C型1（MRC1）编码人甘露糖受体（MR），是C型凝集素受体家族的成员。它通过细胞外结构识别并结合结核分枝杆菌。它在抗原呈递和维持内部环境稳定中发挥作用。它在控制免疫反应和调节哮喘的过敏原诱导性过敏反应方面起关键作用。该基因通过受体细胞质尾部与HSP70家族成员一起协助巨噬细胞的MR转运。
Features and Benefits
Prestige抗体®是经过高度表征和广泛验证的抗体，同时还有一个优点是其每个靶标的所有可用表征数据都可以通过位于此页面顶部产品名称下方的人类蛋白质图谱门户进行访问。Prestige抗体对其他蛋白质的独特性和低交叉反应性®是通过严密的抗原区域选择、亲和纯化和严格的选择来实现的。针对每一个Prestige 抗体都存在有对应的Prestige抗原对照，并可在链接区域内找到。
每个Prestige 抗体都是按照以下方法进行测试的：
每个Prestige 抗体都是按照以下方法进行测试的：
- 44例正常人类组织以及20例最常见癌症类型组织的IHC组织阵列。
- 364个人类重组蛋白片段的蛋白阵列。
Physical form
溶于磷酸盐缓冲盐水，pH 7.2，含有40%甘油和0.02%叠氮化钠
Other Notes
对应抗原APREST86249
Legal Information
Prestige Antibodies is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、体外或体内治疗用途，或人类或动物任何类型的消费或使用。
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存储类别
10 - Combustible liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
法规信息
常规特殊物品
低风险生物材料
此项目有
The sdLDL reduces MRC1 expression level and secretion of Histamin e in differentiated M2-macrophages from patients with coronary artery stenosis
Yarnazari A, et al.
Cardiovascular & Hematological Disorders Drug Targets, 17(1), 28-32 (2017)
Netrin-1 is associated with macrophage infiltration and polarization in human epicardial adipose tissue in coronary artery disease
Gurses K M, et al.
Journal of Cardiology, 69(6), 851-858 (2017)
Ying-Ming Tsai et al.
PloS one, 8(5), e64105-e64105 (2013-06-05)
The innate pattern recognition C-type-lectin receptors (CLRs), including mannose receptor (MRC1; CD206), have been suggested to functionally interact with allergens and are critical in controlling immune response. Fibrocytes have been considered to play a role in allergic asthma. Here we
Li Liu et al.
JCI insight, 4(4) (2019-03-05)
Newly emerging viruses, such as severe acute respiratory syndrome coronavirus (SARS-CoV), Middle Eastern respiratory syndrome CoVs (MERS-CoV), and H7N9, cause fatal acute lung injury (ALI) by driving hypercytokinemia and aggressive inflammation through mechanisms that remain elusive. In SARS-CoV/macaque models, we
M Mark et al.
ESMO open, 7(3), 100446-100446 (2022-04-16)
The SAKK 17/16 study showed promising efficacy data with lurbinectedin as second- or third-line palliative therapy in malignant pleural mesothelioma. Here, we evaluated long-term outcome and analyzed the impact of lurbinectedin monotherapy on the tumor microenvironment at the cellular and
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