Anti-USP2 antibody produced in rabbit

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USP2 (Ubiquitin specific peptidase 2) is primarily associated in the regulation of Mdm2/p53 pathway. It directly interacts and deubiquitinates murine double minute 2 (MDM2) without affecting p53 ubiquitination. Overexpressed USP2 triggers Mdm2 storage in cells, which further promotes p53 degradation. Due to the tumor suppressive property, it may have clinical importance in cancer therapy. It is also involved in the negative regulation of the NF-κB (nuclear factor κB) activation pathway. Studies show that the upregulated USP2 plays a vital role in the mesangial cell proliferation during glomerulonephritides.

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• IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues.
• Protein array of 364 human recombinant protein fragments.

USP2 (Ubiquitin specific peptidase 2) is a 69kDa protein belonging to the de-ubiquitinating enzyme family. It is highly expressed in the kidney tissue and responsible for the cell growth regulation and differentiation.

Ubiquitin carboxyl-terminal hydrolase 2 recombinant protein epitope signature tag (PrEST)

Corresponding Antigen APREST70773

Solution in phosphate-buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide

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