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Merck
CN

HPA012323

抗CSF1R 兔抗

Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution

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关于此项目

UNSPSC Code:
12352203
NACRES:
NA.41
MDL number:
Human Protein Atlas Number:
Conjugate:
unconjugated
Clone:
polyclonal
Application:
immunoblotting
immunofluorescence
immunohistochemistry
Species reactivity:
human
Citations:
9
Technique(s):
immunoblotting: 0.04-0.4 μg/mL
immunofluorescence: 0.25-2 μg/mL
immunohistochemistry: 1:50-1:200
Uniprot accession no.:
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产品名称

抗CSF1R 兔抗, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution

biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

product line

Prestige Antibodies® Powered by Atlas Antibodies

form

buffered aqueous glycerol solution

species reactivity

human

enhanced validation

recombinant expression
Learn more about Antibody Enhanced Validation

technique(s)

immunoblotting: 0.04-0.4 μg/mL
immunofluorescence: 0.25-2 μg/mL
immunohistochemistry: 1:50-1:200

immunogen sequence

NFDVFLQHNNTKLAIPQQSDFHNNRYQKVLTLNLDQVDFQHAGNYSCVASNVQGKHSTSMFFRVVESAYLNLSSEQNLIQEVTVGEGLNLKVMVEAYPGLQGFNWTYLGPFSDHQP

UniProt accession no.

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Quality Level

Gene Information

human ... CSF1R(1436)

Biochem/physiol Actions

CSF1R(集落刺激因子1受体)是先天性免疫、癌症和炎性疾病(包括系统性红斑狼疮、关节炎、动脉粥样硬化和肥胖)的主要分子。它调节发育活动,包括细胞存活、增殖、分化和单核吞噬细胞功能。据报道,CSF-1自分泌环有助于激活巨噬细胞。在实际状态下,它以自动抑制的形式存在,一旦激活,它就会二聚化。然后,它使胞内结构域中的酪氨酸残基自磷酸化,随后募集信号分子并内化受体。CSF1R突变会引发多种疾病,包括骨髓恶性肿瘤。

Disclaimer

除非我们的目录或随附于产品的其他公司文档另有说明,否则我们的产品仅供研究使用,不得用于任何其他目的,包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。

Application

CSF1R抗体还可用于:
  • 细胞裂解
  • 免疫沉淀
  • 蛋白印迹
  • 免疫组化分析

Features and Benefits

Prestige抗体®是经过高度表征和广泛验证的抗体,同时还有一个优点是其每个靶标的所有可用表征数据都可以通过位于此页面顶部产品名称下方的人类蛋白质图谱门户进行访问。Prestige抗体对其他蛋白质的独特性和低交叉反应性®是通过严密的抗原区域选择、亲和纯化和严格的选择来实现的。针对每一个Prestige Antibody都存在有对应的Prestige抗原对照,并可在链接区域内找到。

每个Prestige Antibody都是按照以下方法进行测试的:
  • 44例正常人类组织以及20例最常见癌症类型组织的IHC组织阵列。
  • 364个人类重组蛋白片段的蛋白阵列。

General description

CSF1R 位于人类染色体 5q32。
CSF1R(集落刺激因子1受体)是III型受体酪氨酸激酶,是血小板衍生生长因子(PDGF)受体家族的一员。结构上,它由5个免疫球蛋白样结构域、一个跨膜结构域、一个近膜结构域(JM)和一个被插入结构域(KID)分隔成两部分的蛋白激酶结构域组成。

Immunogen

巨噬细胞集落刺激因子 1 受体前体重组蛋白表位信号标签 (PrEST)

Other Notes

对应抗原APREST86535

Physical form

溶于含有40%甘油和0.02%叠氮化钠的磷酸盐缓冲盐水(pH 7.2)。

Legal Information

Prestige Antibodies is a registered trademark of Merck KGaA, Darmstadt, Germany

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存储类别

10 - Combustible liquids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

法规信息

常规特殊物品
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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Harvey I Pass et al.
Oncotarget, 7(35), 56408-56421 (2016-08-04)
In the present work we show that multiple lung cancer cell lines contain cisplatin resistant cell subpopulations expressing the Colony-Stimulating-Factor-Receptor-1 (CSF-1R) and surviving chemotherapy-induced stress. By exploiting siRNA-mediated knock down in vitro and the use of an investigational CSF-1R TKI
Xingchao Wang et al.
Frontiers in oncology, 12, 850767-850767 (2022-04-22)
Colony stimulating factor 1 receptor (CSF-1R) is a single channel III transmembrane receptor tyrosine kinase (RTK) and plays an important role in immune regulation and the development of various cancer types. The expression of CSF-1R in colon adenocarcinoma (COAD) and
Muhammad Baghdadi et al.
Scientific reports, 8(1), 418-418 (2018-01-13)
Despite recent advances in diagnosis and treatment of lung cancers, the 5-year survival rate remains unsatisfactory, which necessitates the identification of novel factors that associates with disease progression and malignant degree for improving diagnostic and therapeutic strategies. Recent progress in
High co-expression of IL-34 and M-CSF correlates with tumor progression and poor survival in lung cancers
Baghdadi M, et al.
Scientific reports, 8(1), 418-418 (2018)
Multi-level whole genome analysis reveals candidate biomarkers in clear cell renal cell carcinoma
Girgis A H, et al.
Cancer research, canres-ca0656 (2012)

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