HPA012615
Anti-DSC2 antibody produced in rabbit
Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution
别名:
Anti-Desmocollin-2 precursor, Anti-Desmocollin-3, Anti-Desmosomal glycoprotein II and III
产品名称
Anti-DSC2 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
product line
Prestige Antibodies® Powered by Atlas Antibodies
form
buffered aqueous glycerol solution
species reactivity
human
enhanced validation
independent
orthogonal RNAseq
Learn more about Antibody Enhanced Validation
technique(s)
immunohistochemistry: 1:200- 1:500
immunogen sequence
KTVIICKPTMSSAEIVAVDPDEPIHGPPFDFSLESSTSEVQRMWRLKAINDTAARLSYQNDPPFGSYVVPITVRDRLGMSSVTSLDVTLCDCITENDCTHRVDPRIGGGGVQLGKW
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... DSC2(1824)
Application
Anti-DSC2 antibody produced in rabbit, a Prestige Antibody, is developed and validated by the Human Protein Atlas (HPA) project . Each antibody is tested by immunohistochemistry against hundreds of normal and disease tissues. These images can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. The antibodies are also tested using immunofluorescence and western blotting. To view these protocols and other useful information about Prestige Antibodies and the HPA, visit sigma.com/prestige. Anti-DSC2 antibody produced in rabbit can also be used for immunoprecipitation.
Biochem/physiol Actions
Desmocollin 2 (DSC2) homo- and heterodimerize with each other and links the neighbouring cells by the interactions with the help of their extracellular cadherin domains. The domains also help these proteins to bind to desmogleins in a Ca2+-dependent manner. Its intracellular portions interact with plakoglobin (PG) and plakophilin-2 (PKP2). These two proteins in turn bind to desmoplakin (DSP) and provide a link to intermediate filaments. Mutations in the gene encoding DSC2 lead to arrhythmogenic right ventricular cardiomyopathy. DSC2 is essential for the establishment of early cardiac morphogenesis, normal myocardial structure and function and desmosome formation.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Features and Benefits
Prestige Antibodies® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.
Every Prestige Antibody is tested in the following ways:
Every Prestige Antibody is tested in the following ways:
- IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues.
- Protein array of 364 human recombinant protein fragments.
General description
Desmocollin 2 (DSC2) is a type I membrane glycoprotein that is localized in the cardiac tissue and other desmosome-containing tissues. It is expressed as two different splice variants with different carboxy-termini. DSC2a isoform possesses a larger cytoplasmic domain than the DSC2b isoform. The gene encoding this protein is present on chromosome 18. DSC2 contains four extracellular amino terminal domains, that is, an extracellular anchor domain (EA), a short transmembrane domain (TM), an intracellular anchor domain (IA), and an intracellular cadherin-binding domain (ICS). It has a single transmembrane domain and a cytoplasmic tail at the carboxy terminus.
Immunogen
Desmocollin-2 precursor recombinant protein epitope signature tag (PrEST)
Other Notes
Corresponding Antigen APREST72496
Physical form
Solution in phosphate-buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide
Legal Information
Prestige Antibodies is a registered trademark of Merck KGaA, Darmstadt, Germany
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存储类别
10 - Combustible liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
法规信息
新产品
此项目有
Arrhythmogenic right ventricular dysplasia/cardiomyopathy associated with mutations in the desmosomal gene desmocollin-2.
P Syriss
American Journal of Human Genetics, 79(5), 978-984 (2006)
Homozygous founder mutation in desmocollin-2 (DSC2) causes arrhythmogenic cardiomyopathy in the Hutterite population.
B Gerull et. al.
Circulation. Cardiovascular Genetics, 6(4), 327-336 (2013)
Brenda Gerull et al.
Circulation. Cardiovascular genetics, 6(4), 327-336 (2013-07-19)
Dominant mutations in cellular junction proteins are the major cause of arrhythmogenic cardiomyopathy, whereas recessive mutations in those proteins cause cardiocutaneous syndromes such as Naxos and Carvajal syndrome. The Hutterites are distinct genetic isolates who settled in North America in
Arnd Heuser et al.
American journal of human genetics, 79(6), 1081-1088 (2006-12-23)
Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a genetically heterogeneous heart-muscle disorder characterized by progressive fibrofatty replacement of right ventricular myocardium and an increased risk of sudden cardiac death. Mutations in desmosomal proteins that cause ARVC have been previously described; therefore
Katja Gehmlich et al.
Cardiovascular research, 90(1), 77-87 (2010-11-11)
Recent immunohistochemical studies observed the loss of plakoglobin (PG) from the intercalated disc (ID) as a hallmark of arrhythmogenic right ventricular cardiomyopathy (ARVC), suggesting a final common pathway for this disease. However, the underlying molecular processes are poorly understood. We
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