Anti-YARS antibody produced in rabbit

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The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. We also provide Prestige Antibodies^® protocols and other useful information.

Tyrosyl-tRNA synthetase (YARS) takes part in the two-step aminoacylation reaction, forming a tRNA bound to a tyrosyl moiety (Tyr-tRNA^Tyr). YARS also takes part in DNA damage protection. During oxidative stress, it translocates from the cytosol to the nucleus and stimulates transcription factors like E2F1 to upregulate the transcription of genes involved in DNA damage repair. Mutations in the gene encoding YARS are associated with Charcot-Marie-Tooth disease (CMT). Studies have shown that it might be an important therapeutic target for chemotherapy-induced thrombocytopenia.

Prestige Antibodies^® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies^® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.

Every Prestige Antibody is tested in the following ways:

• IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues.
• Protein array of 364 human recombinant protein fragments.

Tyrosyl-tRNA synthetase (YARS) belongs to class I of the tRNA synthetase family. It has an amino-terminal catalytic core domain and an endothelial monocyte-activating polypeptide-II (EMAP II)-like carboxyl-terminal domain.

Tyrosyl-tRNA synthetase, cytoplasmic recombinant protein epitope signature tag (PrEST)

Corresponding Antigen APREST74193

Solution in phosphate-buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide

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