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Merck
CN

HPA017960

抗-CORO2B 兔抗

Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution

别名:

抗-Clipin-C, 抗-冠状-2B, 抗-冠状蛋白C, 抗-蛋白 FC96

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关于此项目

UNSPSC Code:
12352203
NACRES:
NA.41
Human Protein Atlas Number:
Conjugate:
unconjugated
Clone:
polyclonal
Application:
IF, IHC
Citations:
6
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biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

product line

Prestige Antibodies® Powered by Atlas Antibodies

form

buffered aqueous glycerol solution

species reactivity

human

enhanced validation

orthogonal RNAseq
Learn more about Antibody Enhanced Validation

technique(s)

immunofluorescence: 0.25-2 μg/mL, immunohistochemistry: 1:200-1:500

immunogen sequence

YQEDIYPMTPGTEPALTPDEWLGGINRDPVLMSLKEGYKKSSKMVFKAPIKEKKSVVVNGIDLLENVPPRTENELLRMFFRQQDEIRRLKEELAQKDIRIRQLQ

UniProt accession no.

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Quality Level

Gene Information

human ... CORO2B(10391)

General description

冠蛋白肌动蛋白结合蛋白2B(CORO2B)属于冠蛋白样蛋白(Clipin)家族,是II型冠蛋白亚型。它在脑内表达,具有WD结构域和α-螺旋区。编码CORO2B的基因位于人类15号染色体上。

Immunogen

冠蛋白-2B重组蛋白表位标签(PrEST)

Application

由Atlas Antibodies提供技术支持的所有Prestige Antibodies抗体均由人类蛋白质图集(HPA)项目开发和验证,因此受到业内最广泛的表征支持。

人类蛋白质图集项目可以分为三大部分: 人体组织图谱、癌症图谱和人类细胞图谱。在组织和癌症图谱项目支持下产生的抗体已通过对数百种正常和疾病组织的免疫组织化学分析得到了验证,并且通过近期人类细胞图谱项目的努力,许多抗体已经过免疫荧光分析的表征,从而绘制人类蛋白质组图谱,不仅是在组织水平上,现在已经达到亚细胞水平。在人类蛋白质图集项目网站上单击图像库链接,可以查看这些图像和庞大的数据集。我们还提供Prestige Antibodies® 抗体的实验方案和其他有用信息。

Biochem/physiol Actions

冠蛋白肌动蛋白结合蛋白2B(CORO2B)是质膜与肌动蛋白细胞骨架之间横桥的组成部分。CORO2B也可能参与神经元肌动蛋白的重排。

Features and Benefits

Prestige抗体®是经过高度表征和广泛验证的抗体,同时还有一个优点是其每个靶标的所有可用表征数据都可以通过位于此页面顶部产品名称下方的人类蛋白质图谱门户进行访问。Prestige抗体对其他蛋白质的独特性和低交叉反应性®是通过严密的抗原区域选择、亲和纯化和严格的选择来实现的。针对每一个Prestige Antibody都存在有对应的Prestige抗原对照,并可在链接区域内找到。

每个Prestige Antibody都是按照以下方法进行测试的:
  • 44例正常人类组织以及20例最常见癌症类型组织的IHC组织阵列。
  • 364个人类重组蛋白片段的蛋白阵列。

Physical form

溶于磷酸盐缓冲盐水,pH 7.2,含有40%甘油和0.02%叠氮化钠

Other Notes

对应抗原APREST72566

Legal Information

Prestige Antibodies is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

除非我们的产品目录或产品附带的其他公司文档另有说明,否则我们的产品仅供研究使用,不得用于任何其他目的,包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。

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存储类别

10 - Combustible liquids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

法规信息

常规特殊物品
低风险生物材料
此项目有

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Keefe T Chan et al.
Trends in cell biology, 21(8), 481-488 (2011-06-03)
Coronins are a conserved family of actin cytoskeleton regulators that promote cell motility and modulate other actin-dependent processes. Although these proteins have been known for 20 years, substantial progress has been made in the past 5 years towards their understanding.
Z M Ahmed et al.
Clinical genetics, 75(1), 86-91 (2008-05-29)
Usher syndrome (USH) is a hereditary disorder associated with sensorineural hearing impairment, progressive loss of vision attributable to retinitis pigmentosa (RP) and variable vestibular function. Three clinical types have been described with type I (USH1) being the most severe. To
Yuewen Chen et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 43(2), 211-220 (2023-01-15)
In the developing cortex, excitatory neurons migrate along the radial fibers to their final destinations and build up synaptic connection with each other to form functional circuitry. The shaping of neuronal morphologies by actin cytoskeleton dynamics is crucial for neuronal
Hongjiao Wu et al.
Cell death & disease, 15(6), 457-457 (2024-06-28)
In eukaryotes, the nucleolus is the critical non-membranous organelle within nuclei that is responsible for ribosomal DNA (rDNA) transcription and ribosome biogenesis. The transcription of rDNA, a rate-limiting step for ribosome biogenesis, is tightly regulated to meet the demand for
T Nakamura et al.
The Journal of biological chemistry, 274(19), 13322-13327 (1999-05-01)
Brain-enriched human FC96 protein shows a close sequence similarity to the Dictyostelium actin-binding protein coronin, which has been implicated in cell motility, cytokinesis, and phagocytosis. A phylogenetic tree analysis revealed that FC96 and two other mammalian molecules (p57 and IR10)

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