Anti-ZNF346 antibody produced in rabbit

The gene ZNF346 (zinc finger protein-346) is mapped to human chromosome 5q35.2. ZNF346 is ubiquitously expressed in tissues. The protein shuttles between the cytoplasm and the nucleus. ZNF346 is also called as JAZ (Just another zinc finger protein).

Zinc finger protein 346 recombinant protein epitope signature tag (PrEST)

All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project and as a result, are supported by the most extensive characterization in the industry.

The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. We also provide Prestige Antibodies^® protocols and other useful information.

Zinc finger protein-346 (ZNF346) binds dsRNA (double stranded RNA) with high affinity through C2H2 zinc fingers. ZNF346 binds and inhibits E2F1 (transcription factor), thus suppressing G1/S transition. Presence of ZNF346 protects cerebellar granule neurons against potassium deprivation-induced death and cortical neurons from death resulting from oxidative stress. ZNF346 stimulates expression of p21, a cell cycle inhibitor known to have neuroprotective effects.

Prestige Antibodies^® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies^® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.

Every Prestige Antibody is tested in the following ways:

• IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues.
• Protein array of 364 human recombinant protein fragments.

Solution in phosphate-buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide

Corresponding Antigen APREST74178

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