Anti-RABEP1 antibody produced in rabbit

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The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. We also provide Prestige Antibodies^® protocols and other useful information.

RABEP1 (Rabaptin, RAB GTPase binding effector protein 1) is a Rab effector protein. During membrane docking and fusion, its C-terminal domain form a dyad-symmetric Rab5-Rabaptin5(2)-Rab5 ternary complex by binding to their switch and interswitch regions. Any mutation in Rab5-Rabaptin5(2)-Rab5 binding causes enlarged endosomes. RABEP1 also participates in K(V)10.1 potassium channel trafficking on the cell surface. It has been reported that silencing of RABEP1 shows induced down-regulation of recycling of K(V)10.1 channel.

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Prestige Antibodies^® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies^® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.

Every Prestige Antibody is tested in the following ways:

• IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues.
• Protein array of 364 human recombinant protein fragments.

RABEP1 (Rabaptin, RAB GTPase binding effector protein 1) is a novel 100kDa cytosolic protein consisting of coiled-coil domain. It is colocalized on large early endosomes.

Rab GTPase-binding effector protein 1 recombinant protein epitope signature tag (PrEST)

Corresponding Antigen APREST74234

Solution in phosphate-buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide

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