Anti-WIPI2 antibody produced in rabbit

All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project and as a result, are supported by the most extensive characterization in the industry.

The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. We also provide Prestige Antibodies^® protocols and other useful information.

WIPI2 (WD repeat domain, phosphoinositide interacting 2) is involved in the regulation of starvation-induced autophagy. It directly interacts to the Atg12-5-16L1 complex upstream of Atg16L1. During starvation-induced autophagy, this interaction further facilitates PtdIns(3)P-dependent recruitment of Atg12-5-16L1 to the omegasome and phagophore. It also plays an essential role in the innate immune response to Salmonella Typhimurium infection by initiating several responses such as the introduction of Atg16L1, initiation of LC3 lipid conjugation, autophagosomal membrane formation, and blocking of bacterial proliferation.

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Prestige Antibodies^® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies^® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.

Every Prestige Antibody is tested in the following ways:

• IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues.
• Protein array of 364 human recombinant protein fragments.

WIPI2 (WD repeat domain, phosphoinositide interacting 2) is a WD-repeat PtdIns(3)P (phosphatidylinositol 3-phosphate) effector protein expressed in the endoplasmic reticulum. It is expressed in different cell lines. WIPI2 exists in five isoforms (a, b, c, d, and e).

WD repeat domain phosphoinositide-interacting protein 2 recombinant protein epitope signature tag (PrEST)

Corresponding Antigen APREST75037

Solution in phosphate-buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide

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