HPA027366
Anti-HTRA2 antibody produced in rabbit
Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution
别名:
Anti-High temperature requirement protein A2, Anti-HtrA2, Anti-Omi stress-regulated endoprotease, Anti-Serine protease 25, Anti-Serine protease HTRA2, mitochondrial, Anti-Serine proteinase OMI
产品名称
Anti-HTRA2 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
product line
Prestige Antibodies® Powered by Atlas Antibodies
form
buffered aqueous glycerol solution
species reactivity
human
enhanced validation
recombinant expression
Learn more about Antibody Enhanced Validation
technique(s)
immunoblotting: 0.04-0.4 μg/mL
immunohistochemistry: 1:200-1:500
immunogen sequence
MAAPRAGRGAGWSLRAWRALGGIRWGRRPRLTPDLRALLTSGTSDPRARVTYGTPSLWARLSVGVTEPRACLTSGTPGPRAQLTAVTPDTRTREASENSGTRSR
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... HTRA2(27429)
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Application
All Prestige Antibodies®Powered by Atlas Antibodies is developed and validated by the Human Protein Atlas (HPA) project . Each antibody is tested by immunohistochemistry against hundreds of normal and disease tissues. These images can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. We also provide Prestige Antibodies® protocols and other useful information.
Anti-HTRA2 antibody produced in rabbit has been used in western blotting.
Anti-HTRA2 antibody produced in rabbit has been used in western blotting.
Biochem/physiol Actions
HTRA2 (high temperature requirement protein A2) is a mitochondrial serine protease and is associated with various neurodegenerative disorders. HTRA proteases recognize the exposed hydrophobic areas in proteins and are responsible for their degradation. It helps in mitochondrial homeostasis and plays a proapoptotic role in the cytoplasm. It is also involved in the development of cancer. It might be associated with various cancers due to its apoptotic function.
Features and Benefits
Prestige Antibodies® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.
Every Prestige Antibody is tested in the following ways:
Every Prestige Antibody is tested in the following ways:
- IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues.
- Protein array of 364 human recombinant protein fragments.
General description
The gene HTRA2 (high temperature requirement protein A2) is mapped to human chromosome 2p13. The encoded protein has a PDZ (postsynaptic density of 95 kDa, disc large and zonula occludens 1) domain and a protease domain. It is mainly present in the mitochondrial intermembrane space and goes to the cytoplasm in presence of cellular stress.
Immunogen
Serine protease HTRA2, mitochondrial Precursor recombinant protein epitope signature tag (PrEST)
Other Notes
Corresponding Antigen APREST70804
Physical form
Solution in phosphate-buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide
Legal Information
Prestige Antibodies is a registered trademark of Merck KGaA, Darmstadt, Germany
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存储类别
10 - Combustible liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
Lyme disease spirochaetes possess an aggrecan-binding protease with aggrecanase activity.
Russell TM and Johnson BJ
Molecular Microbiology, 90, 228-240 (2013)
Parkinson's disease: a genetic perspective.
Belin AC and Westerlund M
FEBS Journal, 275, 1377-1383 (2008)
Stress Conditions Increase Vimentin Cleavage by Omi/HtrA2 Protease in Human Primary Neurons and Differentiated Neuroblastoma Cells.
Lucotte B, et al.
Molecular Neurobiology, 52, 1077-1092 (2015)
High-temperature-required protein A2 as a predictive marker for response to chemotherapy and prognosis in patients with high-grade serous ovarian cancers.
Miyamoto M, et al.
British Journal of Cancer, 112, 739-744 (2015)
Intra- and intersubunit changes accompanying thermal activation of the HtrA2(Omi) protease homotrimer.
Jarzab M, et al.
Biochimica et Biophysica Acta, 1864, 283-296 (2016)
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