HPA040825
Anti-IP6K1 antibody produced in rabbit
Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution
别名:
Anti-IHPK1, Anti-Inositol hexakisphosphate kinase 1, Anti-KIAA0263
产品名称
Anti-IP6K1 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
product line
Prestige Antibodies® Powered by Atlas Antibodies
form
buffered aqueous glycerol solution
species reactivity
human
technique(s)
immunoblotting: 0.04-0.4 μg/mL
immunofluorescence: 0.25-2 μg/mL
immunogen sequence
DSDGYINLVAYPYVESETVEQDDTTEREQPRRKHSRRSLHRSGSGSDHKEEKASLSLETSESSQEAKSP
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... IP6K1(9807)
Application
Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
- Western Blotting (1 paper).
- immunofluorescence.
- fluorescence-activated cell sorting (FACS).
Biochem/physiol Actions
Inositol hexakisphosphate kinase 1 (IP6K1) is involved in the synthesis of diphosphoinositol pentakisphosphate. It interacts with cullin–RING ubiquitin ligase-4 (CRL4) and has a role in DNA homologous recombination repair. In addition, IP6K1 is also implicated in chromatin modifications and spermatogenesis. Elevated expression or mutation of IP6K1 is associated with the pathogenesis of type 2 diabetes mellitus and crohn′s disease. IP6K1 plays a vital role in dynein-dependent trafficking pathways, including endosomal sorting, vesicle movement and Golgi maintenance. IP6K1 controls DNA repair and cell death by mediating disassembly of the cullin-RING ubiquitin ligase 4 (CRL4)-COP9 signalosome (CSN) complex.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Features and Benefits
Prestige Antibodies® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.
Every Prestige Antibody is tested in the following ways:
Every Prestige Antibody is tested in the following ways:
- IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues.
- Protein array of 364 human recombinant protein fragments.
General description
Inositol hexakisphosphate kinase (IP6K1) is encoded by the gene mapped to human chromosome 3p21.31. The encoded protein belongs to the family of inositol hexakisphosphate (IP6) proteins and is widely expressed.
Immunogen
inositol hexakisphosphate kinase 1 recombinant protein epitope signature tag (PrEST)
Other Notes
Corresponding Antigen APREST79496
Physical form
Solution in phosphate buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide.
Legal Information
Prestige Antibodies is a registered trademark of Merck KGaA, Darmstadt, Germany
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存储类别
10 - Combustible liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
此项目有
Inositol hexakisphosphate kinase 1 (IP6K1) activity is required for cytoplasmic dynein-driven transport.
Chanduri M
The Biochemical Journal, 473(19), 3031-3047 (2016)
Contribution of polymorphic variation of inositol hexakisphosphate kinase 3 (IP6K3) gene promoter to the susceptibility to late onset Alzheimer's disease.
Crocco P
Biochimica et Biophysica Acta, 1862(9), 1766-1773 (2016)
Characterization of a selective inhibitor of inositol hexakisphosphate kinases: use in defining biological roles and metabolic relationships of inositol pyrophosphates.
Padmanabhan U
The Journal of Biological Chemistry, 284(16), 10571-10582 (2009)
Rathan S Jadav et al.
Cellular signalling, 28(8), 1124-1136 (2016-05-04)
Inositol hexakisphosphate kinases (IP6Ks), a family of enzymes found in all eukaryotes, are responsible for the synthesis of 5-diphosphoinositol pentakisphosphate (5-IP7) from inositol hexakisphosphate (IP6). Three isoforms of IP6Ks are found in mammals, and gene deletions of each isoform lead
Masatoshi Ito et al.
The Journal of biological chemistry, 299(3), 102928-102928 (2023-01-22)
Inositol pyrophosphates regulate diverse physiological processes; to better understand their functional roles, assessing their tissue-specific distribution is important. Here, we profiled inositol pyrophosphate levels in mammalian organs using an originally designed liquid chromatography-mass spectrometry (LC-MS) protocol and discovered that the
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