Anti-SPRED1 antibody produced in rabbit

Sprouty related EVH1 domain containing 1 (SPRED1) is encoded by the gene mapped to human chromosome 15q14. The encoded protein belongs to the SPROUTY/SPRED family of proteins. SPRED1 is predominantly expressed in hematopoietic cells.

sprouty-related, EVH1 domain containing 1 recombinant protein epitope signature tag (PrEST)

All Prestige Antibodies^® Powered by Atlas Antibodies is developed and validated by the Human Protein Atlas (HPA) project . Each antibody is tested by immunohistochemistry against hundreds of normal and disease tissues. These images can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. We also provide Prestige Antibodies^® protocols and other useful information.

Anti-SPRED1 antibody produced in rabbit has been used in immunohistochemistry.

Sprouty related EVH1 domain containing 1 (SPRED1) acts as a negative regulator of Ras by hindering the phosphorylation of Raf. The encoded protein negatively regulates mast cell activation and high affinity immunoglobulin E receptor (FcεRI)-mediated cytokine production, which is controlled by miR126. SPRED1 also plays a vital role in neural and behavioral plasticity. Mutation in the gene leads to legius syndrome and neurofibromatosis type 1 (NF1)-like syndrome (NFLS).

Prestige Antibodies^® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies^® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.

Every Prestige Antibody is tested in the following ways:

• IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues.
• Protein array of 364 human recombinant protein fragments.

Solution in phosphate buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide.

Corresponding Antigen APREST81524

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