产品名称
甲醛溶液，中性缓冲，10%, case of 24 × 60 mL, histological tissue fixative
SMILES string
[O-]#[C+H2]
InChI
1S/CH2O/c1-2/h1H2
InChI key
WSFSSNUMVMOOMR-UHFFFAOYSA-N
biological source
synthetic
packaging
case of 24 × 60 mL
concentration
10% formalin (approx. 4% formaldehyde)
color
colorless
pH
6.90-7.10
density
1.080 g/cm3
application(s)
hematology
histology
storage temp.
room temp
Quality Level
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Application
常用的通用组织学固定剂。
福尔马林溶液（中性缓冲，10%）已广泛用于固定组织样本的通用组织学固定剂。
General description
福尔马林溶液（10%，中性缓冲）是一种广泛用于光学显微镜处理样品的固定剂。它需要相对较短的固定时间。它适用于长期储存组织。一旦被正确固定后，组织应该可以承受后续的组织处理或染色阶段。
Packaging
箱体容器是带有白色防漏盖的聚丙烯，部分预填充了10％NBF。
Physical form
中性缓冲的溶液
Biochem/physiol Actions
Formaldehyde is both a non-coagulant and an additive fixative. Formalin fixation is thought to form cross links between the aldehydes and the proteins, creating a gel, thus retaining cellular constituents in their in vivo relationship. Formaldehyde is known to penetrate tissue quickly, but the fixation process may take a long time to form the various cross links with tissue proteins.
Features and Benefits
- 10% NBF is well-suited for large throughput laboratories.
- It requires a relatively short period of fixation.
- It can be used for the long-term storage of tissue.
signalword
Danger
Hazard Classifications
Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Carc. 1B - Muta. 2 - Skin Sens. 1
wgk
WGK 3
ppe
Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter
Tracking Endocytosis and Intracellular Trafficking of Epitope-tagged Syntaxin 3 by Antibody Feeding in Live, Polarized MDCK Cells.
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Molecular Biology of the Cell (2017)
Dermatophytes activate skin keratinocytes via MAPK signaling and induce immune responses.
Achterman R R, et al.
Infection and Immunity, IAI-02776 (2015)
Histological and Histochemical Methods ? Theory and practice, 5th Edition
J. A. Kiernan
Histological and Histochemical Methods: Theory and Practice (2015)
René J Buesa
Annals of diagnostic pathology, 12(6), 387-396 (2008-11-11)
Because formalin is toxic, carcinogenic, and a poor preserver of nucleic acids, for more than 20 years, there have been numerous attempts to find a substitute, with as many different alternative fixatives, none totally successful. With a fast penetration, formaldehyde
Adam D Pfefferle et al.
Disease models & mechanisms, 12(7) (2019-06-20)
The Wnt gene family encodes an evolutionarily conserved group of proteins that regulate cell growth, differentiation and stem cell self-renewal. Aberrant Wnt signaling in human breast tumors has been proposed as a driver of tumorigenesis, especially in the basal-like tumor
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