产品名称
甲醛溶液，中性缓冲，10%, histological tissue fixative
SMILES string
[O-]#[C+H2]
InChI
1S/CH2O/c1-2/h1H2
InChI key
WSFSSNUMVMOOMR-UHFFFAOYSA-N
concentration
10% formalin (approx. 4% formaldehyde)
color
colorless
pH
6.90-7.10
density
1.080 g/cm3
application(s)
hematology
histology
storage temp.
room temp
Quality Level
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Application
10%中性福尔马林溶液是备受欢迎的通用组织学固定剂。通过防止组织腐败、维持其分子结构来保存组织样本。
常用的通用组织学固定剂。
General description
10%福尔马林中性缓冲液通常用作已被用作光学显微镜的固定剂。它需要相对较短的固定时间。它适用于长期储存组织。一旦被正确固定后，组织应该可以承受后续的组织处理或染色阶段。10% NBF很适合于高通量的实验室，并只需要一段相对短的固定时间，但也可用于组织的长期储存。福尔马林通过让蛋白质分子交联形成凝胶而固定，使细胞保持生活状态时的形态结构。
Packaging
产品包装在一个 20L 的软方桶中，由纸板箱内的塑料气囊和连接的插口组成。
Physical form
中性缓冲的溶液
Biochem/physiol Actions
Formaldehyde is both a non-coagulant and an additive fixative. Formalin fixation is thought to form cross links between the aldehydes and the proteins, creating a gel, thus retaining cellular constituents in their in vivo relationship. Formaldehyde is known to penetrate tissue quickly, but the fixation process may take a long time to form the various cross links with tissue proteins.
Features and Benefits
- 10% NBF is well-suited for large throughput laboratories.
- It requires a relatively short period of fixation.
- It can be used for the long-term storage of tissue.
signalword
Danger
Hazard Classifications
Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Carc. 1B - Muta. 2 - Skin Sens. 1
wgk
WGK 3
ppe
Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter
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Weindel C G, et al
Autophagy, 11(5), 1010-1024 (2015)
Histological and Histochemical Methods ? Theory and practice, 5th Edition
J. A. Kiernan
Histological and Histochemical Methods: Theory and Practice (2015)
Autophagy in Dendritic Cells and B Cells Is Critical for the Inflammatory State of TLR7-Mediated Autoimmunity.
Weindel C G, et al.
Journal of Immunology, 198, 1081-1092 (2016)
Ming-Kai Hsieh et al.
Scientific reports, 10(1), 10441-10441 (2020-06-28)
Screw loosening due to broken pedicles is a common complication resulting from the insertion of screws either with inadequate diameters or into an osteoporotic pedicle. In this novel in vitro study, we tried to clarify the contribution of the pedicle
René J Buesa
Annals of diagnostic pathology, 12(6), 387-396 (2008-11-11)
Because formalin is toxic, carcinogenic, and a poor preserver of nucleic acids, for more than 20 years, there have been numerous attempts to find a substitute, with as many different alternative fixatives, none totally successful. With a fast penetration, formaldehyde
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