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Merck
CN

HT501640

Sigma-Aldrich

甲醛溶液,中性缓冲,10%

histological tissue fixative

别名:

甲醛

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MDL编号:
UNSPSC代码:
12352114
PubChem化学物质编号:
NACRES:
NA.47
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质量水平

浓度

10% formalin (approx. 4% formaldehyde)

颜色

colorless

pH值(酸碱度)

6.90-7.10

密度

1.080 g/cm3

应用

hematology
histology

储存温度

room temp

SMILES字符串

[O-]#[C+H2]

InChI

1S/CH2O/c1-2/h1H2

InChI key

WSFSSNUMVMOOMR-UHFFFAOYSA-N

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一般描述

10%福尔马林中性缓冲液通常用作已被用作光学显微镜的固定剂。它需要相对较短的固定时间。它适用于长期储存组织。一旦被正确固定后,组织应该可以承受后续的组织处理或染色阶段。10% NBF很适合于高通量的实验室,并只需要一段相对短的固定时间,但也可用于组织的长期储存。福尔马林通过让蛋白质分子交联形成凝胶而固定,使细胞保持生活状态时的形态结构。

应用

10%中性福尔马林溶液是备受欢迎的通用组织学固定剂。通过防止组织腐败、维持其分子结构来保存组织样本。
常用的通用组织学固定剂。

生化/生理作用

Formaldehyde is both a non-coagulant and an additive fixative. Formalin fixation is thought to form cross links between the aldehydes and the proteins, creating a gel, thus retaining cellular constituents in their in vivo relationship. Formaldehyde is known to penetrate tissue quickly, but the fixation process may take a long time to form the various cross links with tissue proteins.

特点和优势

  • 10% NBF is well-suited for large throughput laboratories.
  • It requires a relatively short period of fixation.
  • It can be used for the long-term storage of tissue.

包装

产品包装在一个 20L 的软方桶中,由纸板箱内的塑料气囊和连接的插口组成。

外形

中性缓冲的溶液

象形图

Health hazardExclamation mark

警示用语:

Danger

危险分类

Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Carc. 1B - Muta. 2 - Skin Sens. 1

WGK

WGK 3

个人防护装备

Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter


历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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访问文档库

B cell autophagy mediates TLR7-dependent autoimmunity and inflammation.
Weindel C G, et al
Autophagy, 11(5), 1010-1024 (2015)
Histological and Histochemical Methods ? Theory and practice, 5th Edition
J. A. Kiernan
Histological and Histochemical Methods: Theory and Practice (2015)
Autophagy in Dendritic Cells and B Cells Is Critical for the Inflammatory State of TLR7-Mediated Autoimmunity.
Weindel C G, et al.
Journal of Immunology, 198, 1081-1092 (2016)
Ming-Kai Hsieh et al.
Scientific reports, 10(1), 10441-10441 (2020-06-28)
Screw loosening due to broken pedicles is a common complication resulting from the insertion of screws either with inadequate diameters or into an osteoporotic pedicle. In this novel in vitro study, we tried to clarify the contribution of the pedicle
René J Buesa
Annals of diagnostic pathology, 12(6), 387-396 (2008-11-11)
Because formalin is toxic, carcinogenic, and a poor preserver of nucleic acids, for more than 20 years, there have been numerous attempts to find a substitute, with as many different alternative fixatives, none totally successful. With a fast penetration, formaldehyde

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