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Merck
CN

HT501850

Sigma-Aldrich

甲醛溶液,中性缓冲,10%

histological tissue fixative

别名:

甲醛

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MDL编号:
UNSPSC代码:
12171500
PubChem化学物质编号:
NACRES:
NA.47
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生物来源

synthetic

质量水平

浓度

10% formalin (approx. 4% formaldehyde)

颜色

colorless

pH值(酸碱度)

6.90-7.10

密度

1.080 g/cm3

应用

hematology
histology

储存温度

room temp

SMILES字符串

[O-]#[C+H2]

InChI

1S/CH2O/c1-2/h1H2

InChI key

WSFSSNUMVMOOMR-UHFFFAOYSA-N

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一般描述

10% Neutral Buffered Formalin is the most used fixative throughout the world for light microscopy. Formalin solution is the commercially obtained solution containing 37% w/w (40% w/v) of formaldehyde in water. It requires a relatively short period of fixation. It is suitable for the long-term storage of tissue. Once properly fixed, the tissue should be able to withstand the subsequent stages of tissue processing or staining.

应用

10%的福尔马林中性缓冲溶液可用作血液病理学中免疫过氧化物酶法诊断应用的组织初步固定试剂。
常用的通用组织学固定剂。

生化/生理作用

Formaldehyde is both a non-coagulant and an additive fixative. Formalin fixation is thought to form cross links between the aldehydes and the proteins, creating a gel, thus retaining cellular constituents in their in vivo relationship. Formaldehyde is known to penetrate tissue quickly, but the fixation process may take a long time to form the various cross links with tissue proteins.

特点和优势

  • 10% NBF is well-suited for large throughput laboratories.
  • It requires a relatively short period of fixation.
  • It can be used for the long-term storage of tissue.

外形

中性缓冲的溶液

象形图

Health hazardExclamation mark

警示用语:

Danger

危险分类

Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Carc. 1B - Muta. 2 - Skin Sens. 1

WGK

WGK 3

个人防护装备

Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter

法规信息

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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Diagnostic applications of an immunoperoxidase method in hematopathology.
Banks PM.
The Journal of Histochemistry and Cytochemistry, 27(8), 1192-1194 (1979)
Histological and Histochemical Methods ? Theory and practice, 5th Edition
J. A. Kiernan
Histological and Histochemical Methods: Theory and Practice (2015)
Jaehwan Ahn et al.
Biomaterials, 268, 120599-120599 (2020-12-21)
Non-alcoholic fatty liver disease (NAFLD) has become a global pandemic. However, a pharmacological cure has not been approved for NAFLD treatment. The greatest barriers to the development of new treatments are the ambiguous criteria among the NAFLD stages and the
René J Buesa
Annals of diagnostic pathology, 12(6), 387-396 (2008-11-11)
Because formalin is toxic, carcinogenic, and a poor preserver of nucleic acids, for more than 20 years, there have been numerous attempts to find a substitute, with as many different alternative fixatives, none totally successful. With a fast penetration, formaldehyde
Tamara J Nicolson et al.
Diabetes, 58(9), 2070-2083 (2009-06-23)
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