所有图片(1)

文件

I2142

KN-62

Name: KN-62
Brand: SIGMA

≥95%, powder

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别名:

(S)-5-异喹啉磺酸 4-[(2S)-2-[(5-异喹啉磺酰基)甲氨基]-3-氧代-3-(4-苯基-1-哌嗪基)丙基]苯酯, 1-[N,O-二(5-异喹啉磺酰基)-N-甲基-L-型酪氨酸]-4-苯基哌嗪

经验公式（希尔记法）:

C₃₈H₃₅N₅O₆S₂

CAS号:

127191-97-3

分子量:

721.84

MDL编号:

MFCD00083180

PubChem化学物质编号:

24895961

NACRES:

NA.77

生物来源

synthetic (organic)

质量水平

200

检测方案

≥95%

形式

powder

颜色

yellow

mp

130 °C

溶解性

45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 0.93 mg/mL
methanol: 10 mg/mL
DMSO: 12 mg/mL
chloroform: 20 mg/mL

储存温度

−20°C

SMILES string

O=S(OC1=CC=C(C[C@@H](C(N2CCN(C3=CC=CC=C3)CC2)=O)N(C)S(C4=CC=CC5=C4C=CN=C5)(=O)=O)C=C1)(C6=CC=CC7=C6C=CN=C7)=O

InChI

1S/C38H35N5O6S2/c1-41(50(45,46)36-11-5-7-29-26-39-19-17-33(29)36)35(38(44)43-23-21-42(22-24-43)31-9-3-2-4-10-31)25-28-13-15-32(16-14-28)49-51(47,48)37-12-6-8-30-27-40-20-18-34(30)37/h2-20,26-27,35H,21-25H2,1H3/t35-/m0/s1

InChI key

RJVLFQBBRSMWHX-DHUJRADRSA-N

Gene Information

human ... P2RX7(5027)

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生化/生理作用

选择性抑制大鼠脑 Ca²⁺/钙调蛋白依赖性蛋白激酶 II。

特点和优势

《受体分类和信号转导手册》的 Ca/CaMKs和P2受体：P2X离子通道家族页面有该化合物的介绍。想要浏览手册的其他页面，请单击此处。

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

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示例

T1503

货号

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包装规格/数量

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705578-5MG-PW

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MMYOMAG-74K-13

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TGF-β1 prevents up-regulation of the P2X7 receptor by IFN-γ and LPS in leukemic THP-1 monocytes.

Safina Gadeock et al.

Biochimica et biophysica acta, 1798(11), 2058-2066 (2010-07-31)

The P2X7 receptor is an extracellular ATP-gated cation channel critical in inflammation and immunity, and can be up-regulated by IFN-γ and LPS. This study aimed to examine the effect of TGF-β1 on the up-regulation of P2X7 function and expression in

Regina Stark et al.

Science immunology, 3(30) (2018-12-16)

Tissue-resident memory T cells (TRM) are noncirculating immune cells that contribute to the first line of local defense against reinfections. Their location at hotspots of pathogen encounter frequently exposes TRM to tissue damage. This history of danger-signal exposure is an

Antagonists of the P2X(7) receptor. From lead identification to drug development.

Simon D Guile et al.

Journal of medicinal chemistry, 52(10), 3123-3141 (2009-02-05)

Ursolic acid affords antidepressant-like effects in mice through the activation of PKA, PKC, CAMK-II and MEK1/2.

Ana B Ramos-Hryb et al.

Pharmacological reports : PR, 69(6), 1240-1246 (2017-11-13)

Ursolic acid has been shown to display antidepressant-like effects in mice through the modulation of monoaminergic systems. In this study, we sought to investigate the involvement of signaling pathways on the antidepressant-like effects of ursolic acid. Mice were treated orally

Ca(2+)/Calmodulin kinase II and decreases in intracellular pH are required to activate K(+) channels after substantial swelling in villus epithelial cells.

R J MacLeod et al.

The Journal of membrane biology, 172(1), 59-66 (1999-11-07)

To assess the activation of the charybdotoxin-insensitive K(+) channel responsible for Regulatory Volume Decrease (RVD) after substantial volume increases, we measured intracellular pH (pH(i)), intracellular calcium ([Ca(2+)](i)) and inhibitors of kinases and phosphoprotein phosphatases in guinea pig jejunal villus enterocytes

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