I2765
鹅膏氨酸
~95% (TLC), solid, neurotoxin
别名:
α-氨基-3-羟基-5-异噁唑乙酸
登录 查看组织和合同定价。
选择尺寸
关于此项目
经验公式（希尔记法）:
C5H6N2O4
化学文摘社编号:
分子量:
158.11
UNSPSC Code:
12352209
PubChem Substance ID:
NACRES:
NA.32
MDL number:
产品名称
鹅膏氨酸, ~95%, solid
InChI
1S/C5H6N2O4/c6-4(5(9)10)2-1-3(8)7-11-2/h1,4H,6H2,(H,7,8)(H,9,10)
SMILES string
NC(C(O)=O)C1=CC(=O)NO1
InChI key
IRJCBFDCFXCWGO-UHFFFAOYSA-N
assay
~95%
form
solid
color
white
solubility
H2O: 1 mg/mL, clear, colorless (with sonication)
0.1 M NaOH: 10.7 mg/mL
0.1 M HCl: 4.7 mg/mL
Quality Level
Gene Information
rat ... Grm1(24414), Grm2(24415)
正在寻找类似产品? 访问 产品对比指南
Application
鹅膏蕈氨酸作为神经毒素用于大鼠。也可用于诱导猴大脑皮层M1神经元发生原发永久性病变。
鹅膏蕈氨酸被用于成年雄性斑胸草雀 ( Taeniopygia guttata ) 手术，以研究逆转增强剂诱导的发声变化。
Biochem/physiol Actions
对NMDA谷氨酸受体优先选择的非选择性激动剂;神经毒素。
对NMDA谷氨酸受体优先选择的非选择性激动剂;神经毒素。神经兴奋性氨基酸最初分离自鹅膏菌种。
鹅膏蕈氨酸是谷氨酸类似物。参与兴奋细胞体，破坏丘脑网状核（NRT）。它能诱导大量钙离子流入，导致神经元损伤。由于其具有兴奋性毒性功能，鹅膏蕈氨酸用于诱导产生神经退行性变。
Disclaimer
吸湿
signalword
Danger
hcodes
pcodes
Hazard Classifications
Acute Tox. 3 Oral
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
法规信息
高风险级别生物产品--毒素类产品
此项目有
Ludivine Pidoux et al.
eLife, 7 (2018-07-26)
Speech is a complex sensorimotor skill, and vocal learning involves both the basal ganglia and the cerebellum. These subcortical structures interact indirectly through their respective loops with thalamo-cortical and brainstem networks, and directly via subcortical pathways, but the role of
Loïc J Chareyron et al.
Brain structure & function, 222(9), 3899-3914 (2017-05-11)
Hippocampal damage in adult humans impairs episodic and semantic memory, whereas hippocampal damage early in life impairs episodic memory but leaves semantic learning relatively preserved. We have previously shown a similar behavioral dissociation in nonhuman primates. Hippocampal lesion in adult
Samuel A Neymotin et al.
Journal of neuroscience methods, 275, 1-9 (2016-10-18)
Correlated neuronal activity in the brain is hypothesized to contribute to information representation, and is important for gauging brain dynamics in health and disease. Due to high dimensional neural datasets, it is difficult to study temporal variations in correlation structure.
L T Lopes et al.
Acta physiologica (Oxford, England), 211(3), 528-537 (2014-03-13)
Although periaqueductal grey matter activation is known to elicit respiratory and cardiovascular responses, the role of this midbrain area in the compensatory responses to hypoxia is still unknown. To test the participation of the periaqueductal grey matter in cardiorespiratory and
Intrahippocampal administration of ibotenic acid induced cholinergic dysfunction via NR2A/NR2B expression: Implications of resveratrol against Alzheimer disease pathophysiology
Karthick C, et al.
Frontiers in Molecular Neuroscience, 9, 28-28 (2016)
相关内容
Instructions
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持