I2765
鹅膏氨酸
~95% (TLC), solid, neurotoxin
别名:
α-氨基-3-羟基-5-异噁唑乙酸
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关于此项目
经验公式（希尔记法）:
C5H6N2O4
化学文摘社编号:
分子量:
158.11
UNSPSC Code:
12352209
PubChem Substance ID:
NACRES:
NA.32
MDL number:
产品名称
鹅膏氨酸, ~95%, solid
InChI
1S/C5H6N2O4/c6-4(5(9)10)2-1-3(8)7-11-2/h1,4H,6H2,(H,7,8)(H,9,10)
SMILES string
NC(C(O)=O)C1=CC(=O)NO1
InChI key
IRJCBFDCFXCWGO-UHFFFAOYSA-N
assay
~95%
form
solid
color
white
solubility
H2O: 1 mg/mL, clear, colorless (with sonication)
0.1 M NaOH: 10.7 mg/mL
0.1 M HCl: 4.7 mg/mL
Quality Level
Gene Information
rat ... Grm1(24414), Grm2(24415)
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Application
鹅膏蕈氨酸作为神经毒素用于大鼠。也可用于诱导猴大脑皮层M1神经元发生原发永久性病变。
鹅膏蕈氨酸被用于成年雄性斑胸草雀 ( Taeniopygia guttata ) 手术，以研究逆转增强剂诱导的发声变化。
Biochem/physiol Actions
对NMDA谷氨酸受体优先选择的非选择性激动剂;神经毒素。
对NMDA谷氨酸受体优先选择的非选择性激动剂;神经毒素。神经兴奋性氨基酸最初分离自鹅膏菌种。
鹅膏蕈氨酸是谷氨酸类似物。参与兴奋细胞体，破坏丘脑网状核（NRT）。它能诱导大量钙离子流入，导致神经元损伤。由于其具有兴奋性毒性功能，鹅膏蕈氨酸用于诱导产生神经退行性变。
Disclaimer
吸湿
signalword
Danger
hcodes
pcodes
Hazard Classifications
Acute Tox. 3 Oral
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
法规信息
高风险级别生物产品--毒素类产品
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