产品名称
抗-白介素1单克隆抗体β 小鼠抗, clone 8516.311, purified immunoglobulin, lyophilized powder
biological source
mouse
conjugate
unconjugated
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
8516.311, monoclonal
form
lyophilized powder
species reactivity
human
technique(s)
flow cytometry: suitable
immunohistochemistry: 8-25 μg/mL using human PBMC′s
neutralization: suitable
western blot: 1 μg/mL
isotype
IgG1
UniProt accession no.
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... IL1B(3553)
Application
可用于免疫印迹、免疫组织化学、ELISA和中和试验
Biochem/physiol Actions
该抗体能够中和重组人IL-1β的生物活性。不能中和重组人IL-α、重组小鼠IL-1α或重组小鼠IL-1β的活性。固定到微孔板上后，抗体可同时捕获重组和天然人IL-1β。在免疫印迹实验中，该抗体与重组大鼠IL-1β具有~25%交叉反应性，与重组小鼠IL-1β和重组猪IL-1β具有<5%交叉反应性。此外，在免疫印迹实验中，该抗体与重组小鼠IL-α、重组人IL-1ra、重组小鼠IL-1ra或重组大鼠IL-1α无交叉反应性。
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的人类或动物食用或应用。
Immunogen
来自大肠杆菌的纯化重组人IL-1β。
Physical form
从含有5％海藻糖的磷酸盐缓冲生理盐水的0.2μm过滤的溶液中冻干。
Preparation Note
抗白介素-1(IL-1)单克隆抗体（小鼠IgG1亚型）通过蛋白A亲和色谱从小鼠杂交瘤中纯化获得。
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存储类别
13 - Non Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
此项目有
Melanie Genoula et al.
Frontiers in immunology, 9, 459-459 (2018-03-30)
The ability of Mycobacterium tuberculosis (Mtb) to persist in its human host relies on numerous immune evasion strategies, such as the deregulation of the lipid metabolism leading to the formation of foamy macrophages (FM). Yet, the specific host factors leading
Ludmila Alekseeva et al.
BMC microbiology, 9, 33-33 (2009-02-12)
Aspergillus fumigatus, a saprophytic mould, is responsible for life-threatening, invasive pulmonary diseases in immunocompromised hosts. The role of the airway epithelium involves a complex interaction with the inhaled pathogen. Antimicrobial peptides with direct antifungal and chemotactic activities may boost antifungal
Paul A Cordell et al.
Blood, 115(13), 2674-2681 (2010-01-21)
Factor XIII-A (FXIII-A) is present in the cytosol of platelets, megakaryocytes, monocytes, osteoblasts, and macrophages and may be released from cells by a nonclassical pathway. We observed that plasma FXIII-A levels were unchanged in thrombocytopenic mice (Bcl-x(Plt20/Plt20) and Mpl(-/-)), which
Mariángeles Clauzure et al.
Immunology, 163(4), 493-511 (2021-04-10)
The impairment of the cystic fibrosis transmembrane conductance regulator (CFTR) activity induces intracellular chloride (Cl- ) accumulation. The anion Cl- , acting as a second messenger, stimulates the secretion of interleukin-1β (IL-1β), which starts an autocrine positive feedback loop. Here
Tobias Wiedemann et al.
Gut, 61(7), 986-996 (2012-01-31)
One of the most important hormones in the human stomach is the peptide gastrin. It is mainly required for the regulation of gastric pH but is also involved in growth and differentiation of gastric epithelial cells. In Helicobacter pylori infected
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抗体的质量决定了整个免疫检测的成败， 是在选择抗体时首选的考虑因素。基于Sigma®、Chemicon®、Upstate®、Mil l ipore®、 Calbiochem®和Novagen®等子品牌的强强联合，默克在创新的 免疫原设计、免疫、挑选、筛选和验证等方面有着数十年的经验， 创造出许多被广泛使用的抗体，如4G10，Neun，组蛋白修饰等抗 体都是相关领域的“金标”抗体。 我们的技术和科研背景使默克成为高质量抗体的主要设计者和生产 者，而不仅仅是经销商。毋庸置疑，我们的每个小瓶中的抗体都包 含着大量的科学研究成果。
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
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