I4034
Immepip dihydrobromide
≥97% (HPLC), H3 and H4 histamine receptor agonist, powder
别名:
4-(1H-Imidazol-4-ylmethyl)piperidine dihydrobromide
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关于此项目
经验公式（希尔记法）:
C9H17N3Br2
化学文摘社编号:
分子量:
327.06
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77
产品名称
Immepip dihydrobromide, ≥97% (HPLC), powder
质量水平
方案
≥97% (HPLC)
表单
powder
储存条件
desiccated
颜色
white to beige
溶解性
H2O: 10 mg/mL, clear
储存温度
2-8°C
SMILES字符串
Br.Br.C1CNCC(C1)Cc2c[nH]cn2
InChI
1S/C9H15N3.2BrH/c1-2-8(5-10-3-1)4-9-6-11-7-12-9;;/h6-8,10H,1-5H2,(H,11,12);2*1H
InChI key
FXFINNKFZKZVLS-UHFFFAOYSA-N
相关类别
生化/生理作用
H3 and H4 histamine receptor agonist.
Immepip is a H3 and H4 histamine receptor agonist. Immepip is a selective H3 agonist equipotent to (R)-α-methylhistamine and also effective in vitro and in vivo. It is devoid of side activities elicited at H1 and α2 receptors and 5-HT3 receptors.
特点和优势
This compound is featured on the Histamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
警示用语：
Warning
危险声明
危险分类
Acute Tox. 4 Oral
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Jitendra K Singh et al.
Annals of neurosciences, 19(2), 71-75 (2012-04-01)
The histamine H3 receptor is an attractive G protein-coupled receptor drug target that regulates neurotransmission in the central nervous system and plays a crucial role in cognitive and homeostatic functions. This receptor exhibits molecular, pharmacological, and functional heterogeneity that affects
Guadalupe-Elide Morales-Figueroa et al.
Purinergic signalling, 15(1), 85-93 (2018-12-20)
We previously reported that the activation of histamine H3 receptors (H3Rs) selectively counteracts the facilitatory action of adenosine A2A receptors (A2ARs) on GABA release from rat globus pallidus (GP) isolated nerve terminals (synaptosomes). In this work, we examined the mechanisms
Alberto Avila-Luna et al.
Psychopharmacology, 236(6), 1937-1948 (2019-02-15)
Histamine H3 receptors (H3Rs) are co-expressed with dopamine D1 receptors (D1Rs) by striato-nigral medium spiny GABAergic neurons, where they functionally antagonize D1R-mediated responses. We examined whether the chronic administration of the H3R agonist immepip modifies dyskinesias induced by L-3,4-dihydroxyphenylalanine, L-Dopa
Cecilia Flores-Clemente et al.
Neuroscience letters, 641, 77-80 (2017-01-28)
There is evidence for genetic polymorphism within the human histamine H
Balasubramaniam Annamalai et al.
ACS chemical neuroscience, 11(3), 466-476 (2020-01-10)
Reuptake and clearance of released serotonin (5-HT) are critical in serotonergic neurotransmission. Serotonin transporter (SERT) is mainly responsible for clearing the extracellular 5-HT. Controlled trafficking, phosphorylation, and protein stability have been attributed to robust SERT activity. H3 histamine receptors (H3Rs)
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