I5027
抗-干扰素-γ 山羊抗
affinity isolated antibody, lyophilized powder
别名:
抗-IFN-γ
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关于此项目
Conjugate:
unconjugated
Clone:
polyclonal
Application:
IHC, Neutral, WB
Citations:
6
biological source
goat
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
lyophilized powder
species reactivity
mouse, rat
technique(s)
immunohistochemistry: 5-15 μg/mL, neutralization: 0.08-0.2 μg/mL, western blot: 0.1 μg/mL
UniProt accession no.
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
mouse ... Ifng(15978)
rat ... Ifng(25712)
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Immunogen
重组大鼠干扰素-γ在大肠埃希菌表达。
Biochem/physiol Actions
干扰素（IFN）是响应病毒或细菌感染和肿瘤发生而分泌的细胞因子。IFN-γ与由IFNγR1和IFNγR2组成的特异性受体复合物结合。有许多由IFNγ结合介导的途径，例如JAK/STAT1、AP-1、NF-κB、STAT3和STAT5。IFN-γ具有多效性，并执行与免疫反应、炎症、T细胞的分化和活化、细胞周期和凋亡有关的各种功能。
Physical form
从含有5％海藻糖的磷酸盐缓冲盐水的0.2μm过滤的溶液中冻干。
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
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存储类别
13 - Non Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
低风险生物材料
此项目有
Jingjie Wei et al.
BMC endocrine disorders, 22(1), 317-317 (2022-12-14)
IFN-γ is critical for both thyroid and ovarian function, while thyroxine, secreted from the thyroid gland, regulates the ovarian function via the hypothalamus-pituitary -ovary axis. However, the effect of thyroxine on INF-γ involved in the regulation of hypothalamic pituitary ovarian axis
Huixia Chen et al.
Journal of biochemical and molecular toxicology, 38(7), e23761-e23761 (2024-07-02)
Non-small cell cancer (NSCLC) is the most common cancer in the world, but its effective therapeutic methods are limited. Tilianin and sufentanil alleviate various human tumors. This research aimed to clarify the functions and mechanisms of Tilianin and sufentanil in
M Raza Zaidi et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 17(19), 6118-6124 (2011-06-28)
Interferon-γ is a cytokine whose biological activity is conventionally associated with cytostatic/cytotoxic and antitumor mechanisms during cell-mediated adaptive immune response. It has been used clinically to treat a variety of malignancies, albeit with mixed results and side effects that can
Leonidas C Platanias
Nature reviews. Immunology, 5(5), 375-386 (2005-05-03)
Interferons are cytokines that have antiviral, antiproliferative and immunomodulatory effects. Because of these important properties, in the past two decades, major research efforts have been undertaken to understand the signalling mechanisms through which these cytokines induce their effects. Since the
Kate Schroder et al.
Journal of leukocyte biology, 75(2), 163-189 (2003-10-04)
Interferon-gamma (IFN-gamma) coordinates a diverse array of cellular programs through transcriptional regulation of immunologically relevant genes. This article reviews the current understanding of IFN-gamma ligand, receptor, signal transduction, and cellular effects with a focus on macrophage responses and to a
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