产品名称
单克隆抗-人IgG(Fab特异性) 小鼠抗, clone GG-6, ascites fluid
biological source
mouse
conjugate
unconjugated
antibody form
ascites fluid
antibody product type
primary antibodies
clone
GG-6, monoclonal
contains
15 mM sodium azide
technique(s)
indirect ELISA: 1:20,000
isotype
IgG1
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Application
小鼠抗人IgG(Fab特异性)单克隆抗体可用于酶联免疫吸附试验(ELISA)。
Biochem/physiol Actions
单克隆抗人IgG(Fab特异性)对人IgG具有免疫特异性。抗体与IgG的Fab片段反应。
母体IgG通过胎盘到达胎儿,并赋予新生儿抵抗感染的免疫防御能力。IgG与抗体依赖性细胞介导的细胞毒性(ADCC)有关,还使病毒颗粒和毒素无效。IgG的木瓜蛋白酶消化产生抗原结合片段(Fab)。IgG的胃蛋白酶消化产生可结晶片段(fc)片段和单个二聚体F(ab)2。
这些抗体可调节机体对过敏和病原性感染的免疫反应。IgG还与补体结合和自身免疫疾病有关。
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明,否则我们的产品仅供研究使用,不得用于任何其他目的,包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
General description
人IgG是糖蛋白抗体,含有两条相等的轻链和一对相同的重链。IgG具有四种不同亚型,范围从IgG1到IgG4。单克隆抗人IgG(Fab特异性)抗体对人IgG的Fab片段具有特异性。该抗体不与人IgG的Fc部分反应。
单克隆抗-人IgG(Fab特异性)(小鼠 IgG1 亚型)来源于小鼠骨髓瘤细胞与免疫小鼠脾细胞融合产生的杂交瘤。在血液中发现免疫球蛋白G(IgG)。它存在于人血清中,由B细胞分泌。与其他免疫球蛋白相比,IgG的血清半衰期最长。IgG的重链和轻链通过二硫键相互连接。
Immunogen
纯化的人IgG
Physical form
本品为以腹水形式提供,并含有0.1%叠氮化钠(参见MSDS)作为防腐剂。
Preparation Note
若需连续使用,可在0-5℃下保存。若需延长储存时间,可将溶液以工作等分试样冷冻。不建议反复冻融。不建议无霜储存。如果长期储存后发生轻微浑浊,请在使用前通过离心澄清。
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存储类别
10 - Combustible liquids
wgk
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
此项目有
Mario R Romero et al.
Acta odontologica latinoamericana : AOL, 24(2), 176-182 (2011-12-15)
The aim of this study was to measure the level of immunoglobulin A, G and M in saliva of 3- to 12-year-old children, both healthy and diagnosed with gingivitis. A sample of 177 children was selected, of whom 24 were
Ian P Hurley et al.
Forensic science international, 190(1-3), 91-97 (2009-07-07)
The detection and confirmation of bloodstains as being human in origin is important in crime scene investigations. There are a number of blood detection methods currently available. The aim of this work was to develop an assay capable of detecting
Udayan Ray et al.
Journal of thrombosis and thrombolysis, 33(3), 218-229 (2012-01-13)
Insulin inhibits platelet aggregation through nitric oxide synthesis by stimulating platelet insulin activated nitric oxide synthase. Impaired platelet insulin activated nitric oxide synthase in acute myocardial infarction (AMI) patients had been reported and thus our aim was to identify and
Manuel Montesinos-Rongen et al.
Journal of immunology (Baltimore, Md. : 1950), 195(3), 1312-1319 (2015-06-28)
Primary lymphoma of the CNS (PCNSL) is a diffuse large B cell lymphoma confined to the CNS. To elucidate its peculiar organ tropism, we generated recombinant Abs (recAbs) identical to the BCR of 23 PCNSLs from immunocompetent patients. Although none
F Cataldo et al.
Minerva pediatrica, 42(12), 509-514 (1990-12-01)
IgG are the most common isotype of Ig and include four subclasses which differ from one another in the following ways: their initial amino acid sequence, their physical and chemical properties and the different serum concentrations reached with age. Every
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Datasheet
Datasheet
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