I9031
Monoclonal Anti-Intracellular Adhesion Molecule 3 antibody produced in mouse
~1 mg/mL, clone 186-2G9, purified immunoglobulin, buffered aqueous solution
别名:
Anti-ICAM-3
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关于此项目
Conjugate:
unconjugated
Clone:
186-2G9, monoclonal
Application:
FACS, IF (d), IHC, IP, WB
Citations:
2
biological source
mouse
conjugate
unconjugated
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
186-2G9, monoclonal
form
buffered aqueous solution
mol wt
antigen 120 kDa
species reactivity
human
concentration
~1 mg/mL
technique(s)
direct immunofluorescence: 2 μg using 1 mg protein lysate, flow cytometry: 2 μg using 1 mg protein lysate, immunohistochemistry: 2-4 μg/mL using human tonsil tissue sections, immunoprecipitation (IP): 2 μg using 1 mg protein lysate, western blot: 1-5 μg/mL
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... ICAM3(3385)
General description
The gene ICAM3 (intercellular adhesion molecule 3) encodes type I membrane glycoprotein that belongs to the immunoglobulin (ig) superfamily. The encoded protein is extensively glycosylated and contains five Ig-like domains that share high homology with corresponding domains in ICAM-1 and ICAM-2. ICAM3 is found to be expressed on all leukocytes, including the resting leukocytes. The gene is mapped to human chromosome 19p13.2.
Immunogen
stimulated human leukocytes.
Biochem/physiol Actions
The protein intercellular adhesion molecule 3 (ICAM-3) functions as a receptor for LFA-1 (leukocyte function-associated antigen-1) and mediates adhesive interactions of leukocyte cell surface adhesion molecules in inflammatory and immune response. LFA-1 participates in several processes, such as T cell-mediated killing, T helper and B lymphocyte responses, natural killing, Ab-dependent cellular cytotoxicity by monocytes and granulocytes, and adherence of leukocytes to endothelial cells, fibroblasts, and epithelial cells. ICAM-3 mediates the adhesion of resting T lymphocytes to LFA-1 and participates in the initiation of immune responses. It may also function in lymphocyte activation, as well as in adhesion.
Physical form
Solution in phosphate buffered saline pH 7.4, containing 0.08% sodium azide.
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存储类别
10 - Combustible liquids
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
A R de Fougerolles et al.
The Journal of experimental medicine, 179(2), 619-629 (1994-02-01)
We have characterized the immunobiology of the interaction of intercellular adhesion molecule 3 (ICAM-3; CD50) with its counter-receptor, leukocyte function-associated antigen 1 (LFA-1; CD11a/CD18). Purified ICAM-3 supported LFA-1-dependent adhesion in a temperature- and cation-dependent manner. Activation of cells bearing LFA-1
P Kilgannon et al.
Genomics, 54(2), 328-330 (1998-11-26)
Intercellular adhesion molecule 5 (ICAM-5, telencephalin) is a cell adhesion molecule expressed on neurons in the most rostral segment of the mammalian brain, the telencephalon. Antibody studies in rodents and rabbits have demonstrated expression of this molecule on the cell
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