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Merck
CN

I9532

Icilin

≥97% (HPLC), CMR1 receptor agonist, solid

别名:

1-(2-羟基苯基)-4-(3-硝基苯基)-1,2,3,6-四氢­嘧啶-2-酮, AG-3-5

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关于此项目

经验公式(希尔记法):
C16H13N3O4
化学文摘社编号:
分子量:
311.29
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
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产品名称

Icilin, ≥97% (HPLC), solid

SMILES string

Oc1ccccc1N2CC=C(NC2=O)c3cccc(c3)[N+]([O-])=O

InChI

1S/C16H13N3O4/c20-15-7-2-1-6-14(15)18-9-8-13(17-16(18)21)11-4-3-5-12(10-11)19(22)23/h1-8,10,20H,9H2,(H,17,21)

InChI key

RCEFMOGVOYEGJN-UHFFFAOYSA-N

assay

≥97% (HPLC)

form

solid

color

yellow

solubility

DMSO: 15 mg/mL

Quality Level

Application

Icilin已被用作前腹膜内侧前视区(VMPO)神经元的冷却剂。

Biochem/physiol Actions

豌豆球蛋白是CMR1冷和薄荷醇敏感受体的有效激动剂。

General description

Icilin是一种合成的冷却剂,调节人瞬时受体电位阳离子通道(TRPA1)。Icilin抑制瞬时受体电位阳离子通道亚家族M成员8(TRPM8)并调节钙释放。Icilin还抑制瞬时受体电位香草酸亚型3(TRPV3)。

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves


历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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访问文档库

Supercooling agent icilin blocks a warmth-sensing ion channel TRPV3
Sherkheli MA, et al.
TheScientificWorldJournal, 2012(6), 859-869 (2012)
Warm-sensitive neurons that control body temperature
Tan CL, et al.
Cell, 167(1), 47-59 (2016)
Inhibition of TRPM8 by icilin distinct from desensitization induced by menthol and menthol derivatives
Kuhn FJP, et al.
The Journal of Biological Chemistry, 284(7), 4102-4111 (2009)
Dimitra Gkika et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 34(6), 7483-7499 (2020-04-12)
Recent studies have revealed gender differences in cold perception, and pointed to a possible direct action of testosterone (TST) on the cold-activated TRPM8 (Transient Receptor Potential Melastatin Member 8) channel. However, the mechanisms by which TST influences TRPM8-mediated sensory functions
Chong Wang et al.
Journal of cellular and molecular medicine (2020-12-09)
In this study, we investigated the ability of the Polysaccharide from the Eggs of Strongylocentrotus nudus (SEP) to regulate cellular autophagy and apoptosis in leukaemia cells. Human acute myeloid leukaemia (AML) cells (HL60) and murine AML cells (L1210) treated with

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