I9532
Icilin
≥97% (HPLC), CMR1 receptor agonist, solid
别名:
1-（2-羟基苯基）-4-（3-硝基苯基）-1，2，3，6-四氢嘧啶-2-酮, AG-3-5
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关于此项目
经验公式（希尔记法）:
C16H13N3O4
化学文摘社编号:
分子量:
311.29
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
产品名称
Icilin, ≥97% (HPLC), solid
SMILES string
Oc1ccccc1N2CC=C(NC2=O)c3cccc(c3)[N+]([O-])=O
InChI
1S/C16H13N3O4/c20-15-7-2-1-6-14(15)18-9-8-13(17-16(18)21)11-4-3-5-12(10-11)19(22)23/h1-8,10,20H,9H2,(H,17,21)
InChI key
RCEFMOGVOYEGJN-UHFFFAOYSA-N
assay
≥97% (HPLC)
form
solid
color
yellow
solubility
DMSO: 15 mg/mL
Quality Level
Application
Icilin已被用作前腹膜内侧前视区（VMPO）神经元的冷却剂。
Biochem/physiol Actions
豌豆球蛋白是CMR1冷和薄荷醇敏感受体的有效激动剂。
General description
Icilin是一种合成的冷却剂，调节人瞬时受体电位阳离子通道（TRPA1）。Icilin抑制瞬时受体电位阳离子通道亚家族M成员8（TRPM8）并调节钙释放。Icilin还抑制瞬时受体电位香草酸亚型3（TRPV3）。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
Inhibition of TRPM8 by icilin distinct from desensitization induced by menthol and menthol derivatives
Kuhn FJP, et al.
The Journal of Biological Chemistry, 284(7), 4102-4111 (2009)
Supercooling agent icilin blocks a warmth-sensing ion channel TRPV3
Sherkheli MA, et al.
TheScientificWorldJournal, 2012(6), 859-869 (2012)
Warm-sensitive neurons that control body temperature
Tan CL, et al.
Cell, 167(1), 47-59 (2016)
Alexander Lucius et al.
Cellular signalling, 28(3), 136-147 (2015-12-23)
3-Iodothyronamine (3T1AM) is an endogenous thyroid hormone metabolite that interacts with the human trace amine-associated receptor 1 (hTAAR1), a G-protein-coupled receptor, to induce numerous physiological responses including dose-dependent body temperature lowering in rodents. 3T1AM also directly activates cold-sensitive transient receptor
Dimitra Gkika et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 34(6), 7483-7499 (2020-04-12)
Recent studies have revealed gender differences in cold perception, and pointed to a possible direct action of testosterone (TST) on the cold-activated TRPM8 (Transient Receptor Potential Melastatin Member 8) channel. However, the mechanisms by which TST influences TRPM8-mediated sensory functions
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