J4252
JWH-015
≥98% (HPLC), powder
别名:
(2-Methyl-1-propyl-1H-indol-3-yl)-1-naphthalenylmethanone
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关于此项目
经验公式（希尔记法）:
C23H21NO
CAS Number:
分子量:
327.42
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77
质量水平
方案
≥98% (HPLC)
表单
powder
药品控制
regulated under CDSA - not available from Sigma-Aldrich Canada
颜色
off-white
溶解性
DMSO: >20 mg/mL (with heating)
储存温度
−20°C
SMILES字符串
CCCn1c(C)c(C(=O)c2cccc3ccccc23)c4ccccc14
InChI
1S/C23H21NO/c1-3-15-24-16(2)22(20-12-6-7-14-21(20)24)23(25)19-13-8-10-17-9-4-5-11-18(17)19/h4-14H,3,15H2,1-2H3
InChI key
LJSBBBWQTLXQEN-UHFFFAOYSA-N
基因信息
human ... CNR2(1269)
rat ... Cnr1(25248)
应用
JWH-015 has been used to study its effect on tumor-evoked pain behavior. It has also been used to study its protective effects on rat brain mitochondria upon paraquat exposure.
生化/生理作用
JWH-015 is a selective CB2 cannabinoid receptor agonist. JWH-015 is structurally classified as naphthoylindoles.
特点和优势
This compound is featured on the Cannabinoid Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
法规信息
新产品
Joseph E Henriquez et al.
Toxicology and applied pharmacology, 369, 82-89 (2019-02-27)
Plasmacytoid dendritic cells (pDC) compose 0.2-0.5% of circulating leukocytes but play a significant role in mounting host immune responses. Elevated and chronic activation of pDC are implicated in autoimmune disease like systemic lupus erythematosus and rheumatoid arthritis. Δ9-tetrahydrocannabinol (THC) is
G Griffin et al.
European journal of pharmacology, 339(1), 53-61 (1998-02-05)
We have investigated whether there are cannabinoid CB2 receptors that can mediate cannabinoid-induced inhibition of electrically evoked contractions in the mouse vas deferens or guinea-pig myenteric plexus-longitudinal muscle preparation. Our results showed that mouse vas deferens and guinea-pig whole gut
Clinical Toxicology, An Issue of Emergency Medicine Clinics of North America, 4-4 (2014)
Chao Li et al.
Neuroscience letters, 707, 134286-134286 (2019-06-01)
The cannabinoid receptor 2 (CB2R) has been considered as a potential therapeutic target to ameliorate the neuroinflammation and cognitive impairments of Alzheimer's disease (AD). However, there has been little research on the diverse roles of CB2R in regulating different forms
Protective effects of the synthetic cannabinoids CP55, 940 and JWH-015 on rat brain mitochondria upon paraquat exposure
Velez-Pardo C, et al.
Neurochemical Research, 35(9), 1323-1332 (2010)
商品
A large variety of cannabinoid drug standards, along with an HPLC method with the Supelco Ascentis® Express RP-Amide column, are presented in this article.
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