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Merck
CN

J4252

Sigma-Aldrich

JWH-015

≥98% (HPLC), powder

别名:

(2-Methyl-1-propyl-1H-indol-3-yl)-1-naphthalenylmethanone

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关于此项目

经验公式（希尔记法）:
C23H21NO
化学文摘社编号:
155471-08-2
分子量:
327.42
MDL编号:
MFCD02094630
UNSPSC代码:
12352200
PubChem化学物质编号:
24278502
NACRES:
NA.77

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质量水平

100

方案

≥98% (HPLC)

表单

powder

drug control

kontrollierte Droge in Deutschland

药品控制

regulated under CDSA - not available from Sigma-Aldrich Canada

颜色

off-white

溶解性

DMSO: >20 mg/mL (with heating)

储存温度

−20°C

SMILES字符串

CCCn1c(C)c(C(=O)c2cccc3ccccc23)c4ccccc14

InChI

1S/C23H21NO/c1-3-15-24-16(2)22(20-12-6-7-14-21(20)24)23(25)19-13-8-10-17-9-4-5-11-18(17)19/h4-14H,3,15H2,1-2H3

InChI key

LJSBBBWQTLXQEN-UHFFFAOYSA-N

基因信息

human ... CNR2(1269)
rat ... Cnr1(25248)

相关类别

应用

JWH-015 has been used to study its effect on tumor-evoked pain behavior. It has also been used to study its protective effects on rat brain mitochondria upon paraquat exposure.

生化/生理作用

JWH-015 is a selective CB2 cannabinoid receptor agonist. JWH-015 is structurally classified as naphthoylindoles.

特点和优势

This compound is featured on the Cannabinoid Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

法律信息

German
Dieses Produkt fällt unter das Betäubungsmittelgesetz (BtMG). Für eine Bestellung dieses Produktes ist eine Erlaubnis nach § 3 BtMG zwingend erforderlich, es sei denn, es greift eine Ausnahme von der Erlaubnispflicht nach § 4 oder § 26 BtMG.

English
This product is subject to the German Narcotics Act. A permit under Section 3 of the German Narcotics Act is mandatory for ordering this product unless an exemption from the permit requirement under Section 4 or Section 26 of the German Narcotics Act applies.

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

dust mask type N95 (US), Eyeshields, Gloves

法规信息

新产品
此项目有

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
041M4613V
109K47062
109K47061
109K4706
018K4712

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Joseph E Henriquez et al.
Toxicology and applied pharmacology, 369, 82-89 (2019-02-27)
Plasmacytoid dendritic cells (pDC) compose 0.2-0.5% of circulating leukocytes but play a significant role in mounting host immune responses. Elevated and chronic activation of pDC are implicated in autoimmune disease like systemic lupus erythematosus and rheumatoid arthritis. Δ9-tetrahydrocannabinol (THC) is
Clinical Toxicology, An Issue of Emergency Medicine Clinics of North America, 4-4 (2014)
G Griffin et al.
European journal of pharmacology, 339(1), 53-61 (1998-02-05)
We have investigated whether there are cannabinoid CB2 receptors that can mediate cannabinoid-induced inhibition of electrically evoked contractions in the mouse vas deferens or guinea-pig myenteric plexus-longitudinal muscle preparation. Our results showed that mouse vas deferens and guinea-pig whole gut
J W Huffman
Current pharmaceutical design, 6(13), 1323-1337 (2000-07-21)
Following the identification of the CB2 receptor several groups explored the development of selective ligands for this receptor which occurs principally in the periphery. This led to the discovery that two cannabimimetic indoles, 1-(2, 3-dichlorobenzoyl)-2-methyl-3-(2-[1-morpholino]ethyl)-5-methoxyind ole (L768242) and 2-methyl-1-propyl-3-(1-naphthoyl)indole (JWH-015)
Protective effects of the synthetic cannabinoids CP55, 940 and JWH-015 on rat brain mitochondria upon paraquat exposure
Velez-Pardo C, et al.
Neurochemical Research, 35(9), 1323-1332 (2010)
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商品

Synthetic Cannabinoid Analysis

A large variety of cannabinoid drug standards, along with an HPLC method with the Supelco Ascentis® Express RP-Amide column, are presented in this article.

相关内容

Product Information Sheet - J4252

Product Information Sheet

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