K0390
Anti-Potassium Channel K2P1.1 (TWIK-1) 兔抗
affinity isolated antibody, lyophilized powder
别名:
Anti-Inward rectifying potassium channel TWIK-1
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关于此项目
NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
polyclonal
Application:
IHC, WB
Citations:
3
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
lyophilized powder
species reactivity
mouse, human, rat
technique(s)
immunohistochemistry: suitable, western blot: 1:200 using rat brain lysates, western blot: 1:300 using HEK-K2P1.1 transfected cells
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... KCNK1(3775)
mouse ... Kcnk1(16525)
rat ... Kcnk1(59324)
General description
K2P1.1 (also named TWIK-1 or KCNK1) is a member of the 2-pore (2P) domain K+ channels family that at the moment includes 14 members. These channels show little time or voltage dependence and are considered to be "leak" or "background" K+ channels, thereby generating background currents, which help set the membrane resting potential and cell excitation.
The gene K2P1.1 (two pore domain K+ channel), also referred to as KCNK1 (potassium two pore domain channel subfamily K member 1), encodes a protein that spans a length of 337-amino acids. It contains four transmembrane regions and the characteristic sequence of potassium channels in the two pore regions. The protein is found to be exclusively expressed in distal tubule. The gene is mapped to human chromosome 1q42.2.
Immunogen
synthetic peptide RQELRKLKRRFLEEHEC, corresponding to amino acid residues 53-69 of human K2P1.1 (KCNK1).
Biochem/physiol Actions
The gene KCNK1 (potassium two pore domain channel subfamily K member 1) is a double-pore potassium channel that functions in maintaining the renal potassium homeostasis. KCNK channel proteins are involved in cell volume, apoptosis, and proliferation. Alterations in these proteins have been associated with various diseases. Decreased levels of KCNK1 in human cardiac atria have been implicated in chronic atrial fibrillation. It functions as a suppressor of anchorage-independent growth in fibroblast.
Physical form
Lyophilized from pphosphate buffered saline, pH 7.4, containing 1% BSA and 0.025% sodium azide.
Preparation Note
Reconstitute the lyophilized vial with 50 μL or 200 μL deionized water, depending on package size. Further dilutions should be made using a carrier protein such as BSA (1-3%).
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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存储类别
11 - Combustible Solids
wgk
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
低风险生物材料
此项目有
Cloning and localization of a double-pore K channel, KCNK1: exclusive expression in distal nephron segments.
Orias M
The American Journal of Physiology, 273, 663-666 (1997)
Convergent functional genomics of genome-wide association data for bipolar disorder: comprehensive identification of candidate genes, pathways and mechanisms.
Le-Niculescu H
American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics, 150B, 155-181 (2009)
Kosuke Saito et al.
Toxicological sciences : an official journal of the Society of Toxicology, 132(1), 151-161 (2013-01-08)
KCNK1, a member of the family of two-pore K(+) ion channels, is specifically induced in the livers of male mice after phenobarbital treatment. Here, we have determined the molecular mechanism of this male-specific activation of the Kcnk1 gene and characterized
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