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Merck
CN

K0640

Anti-Potassium Channel KV11.1 (HERG) Extracellular-FITC 兔抗

affinity isolated antibody, lyophilized powder

别名:

Anti-KCNH2, Anti-Voltage gated K+ channel subfamily H member 2, Anti-ether-a-go-go-related channel 1

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关于此项目

UNSPSC Code:
12352203
NACRES:
NA.41
MDL number:
MFCD02097212

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产品名称

Anti-Potassium Channel KV11.1 (HERG) Extracellular-FITC 兔抗, affinity isolated antibody, lyophilized powder

biological source

rabbit

conjugate

FITC conjugate

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

lyophilized powder

species reactivity

human

technique(s)

flow cytometry: 2-10 μg/mL using 1x106 human live cells
immunocytochemistry: 1:25 using intact live HEK-KV11.1 transfected cells

UniProt accession no.

Q12809

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Quality Level

200

Gene Information

human ... KCNH2(3757)

相关类别

Application

Flow cytometry: a recommended working concentration of 2-10 μg per 1x106cells was determined using intact live human cells.

Biochem/physiol Actions

The gene Kv11.1, also referred to as HERG (human ether-a-go-go related gene), encodes the α-subunit of the rapid component of the delayed rectifier potassium channel. The third repolarization of the action potential of human cardiomyocytes is carried out by this protein. Mutations in this gene have been associated with type II hereditary long QT syndrome (LQT2). This disease is characterized by prolongation of the QT interval, abnormal T wave, torsade de pointes, syncope and sudden death caused by cardiac arrest.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

Anti-Potassium Channel KV11.1 (HERG)- Extracellular-FITC (Voltage gated K+ channel subfamily H member 2, KCNH2, ether-a-go-go-related channel 1) is produced in rabbit using as immunogen the peptide AFLLKETEEGPPATEC corresponding to residues 430-445 of human KV11.1 (HERG). Anti-KV11.1 (HERG) antibody is directed against an extracellular epitope located between the S1 and S2 domains. The antibody is affinity purified on immobilized antigen and labeled with fluorescein isothiocyanate (FITC).
The gene Kv11.1, also referred to as KCNH2 (potassium voltage-gated channel subfamily H member 2), is mapped to human chromosome 7. The encoded voltage-activated potassium channel is a member of the ether-a-go-go (EAG) family.

Immunogen

peptide AFLLKETEEGPPATEC corresponding to residues 430-445 of human KV11.1 (HERG).

Other Notes

Lyophilized powder can be stored intact at room temperature for several weeks. For extended storage, it should be stored at -20 °C or below. The reconstituted solution can be stored at 2-8 °C for up to 2 weeks. For longer storage, freeze in working aliquots. Avoid repeated freezing and thawing. Storage in “frost-free” freezers is not recommended. Centrifuge before use. Working dilution samples should be discarded if not used within 12 hours. The antibody is stable for at least 12 months when stored appropriately.

Physical form

Lyophilized from phosphate buffered saline, pH 7.4, containing 1% BSA and 0.05% sodium azide.

Preparation Note

Reconstitute the lyophilized vial with 50 μL or 200 μL deionized water, depending on package size. Further dilutions should be made using a carrier protein such as BSA (1-3%).

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存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

法规信息

常规特殊物品
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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000429869
0000429869
SLBK9804
SLCK6059
SLCC4309

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  1. Which document(s) contains shelf-life or expiration date information for a given product?

    If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.

  2. How do I get lot-specific information or a Certificate of Analysis?

    The lot specific COA document can be found by entering the lot number above under the "Documents" section.

  3. How do I find price and availability?

    There are several ways to find pricing and availability for our products. Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote.  USA customers:  1-800-325-3010 or view local office numbers.

  4. What is the Department of Transportation shipping information for this product?

    Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product. 

  5. What is the concentration of Product K0640, Anti-Potassium Channel Kv11.1 (HERG) Extracellular - FITC antibody produced in rabbit after reconstitution with 50 ul of water?

    Product K0640, Anti-Potassium Channel Kv11.1 (HERG) Extracellular - FITC antibody produced in rabbit will have a concentration of 1 mg/ml when reconstituted with 50 ul of water.

  6. My question is not addressed here, how can I contact Technical Service for assistance?

    Ask a Scientist here.

[Progress in research on defective protein trafficking and functional restoration in HERG-associated long QT syndrome].
Fang P and Lian J
Zhonghua yi xue yi chuan xue za zhi (Chinese Journal of Medical Genetics), 33, 101-104 (2016)
Aigul Moldobaeva et al.
Angiogenesis, 20(1), 73-84 (2016-10-28)
Although bronchial angiogenesis has been well documented in allergic asthma, lymphangiogenesis has not been widely studied. Therefore, we evaluated changes in lung lymphatics in a rat model of allergen-induced asthma using house dust mite (Der p 1; 100 μg/challenge). Additionally, properties
Yu-Wen Cheng et al.
International journal of molecular sciences, 24(16) (2023-08-26)
KCNH2 loss-of-function mutations cause long QT syndrome type 2 (LQT2), an inherited cardiac disorder associated with life-threatening ventricular arrhythmia. Through whole-exome sequencing, we discovered a novel AGCGACAC deletion (S981fs) in the hERG gene of an LQT2 patient. Using a heterologous
Xianbin Zhang et al.
Frontiers in oncology, 8, 590-590 (2018-12-21)
In this study we evaluated the interaction of pancreatic cancer cells, cancer-associated fibroblasts, and distinct drugs such as α-cyano-4-hydroxycinnamate, metformin, and gemcitabine. We observed that α-cyano-4-hydroxycinnamate as monotherapy or in combination with metformin could significantly induce collagen I deposition within

相关内容

Data Sheet - K0640

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