L0668
抗LAMP2 兔抗
affinity isolated antibody, buffered aqueous solution
别名:
抗CD107B, 抗LGP110, 抗溶酶体相关膜蛋白2, 抗溶酶体膜糖蛋白B型（LGP-B）
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关于此项目
Conjugate:
unconjugated
Clone:
polyclonal
Application:
indirect immunofluorescence
western blot (chemiluminescent)
western blot (chemiluminescent)
Species reactivity:
human (predicted), mouse, rat
Citations:
51
Technique(s):
indirect immunofluorescence: 10-20 μg/mL using rat NRK and mouse NIH3T3 cells
western blot (chemiluminescent): 2.5-5 μg using whole extract of rat NRK cells
western blot (chemiluminescent): 2.5-5 μg using whole extract of rat NRK cells
Uniprot accession no.:
产品名称
抗LAMP2 兔抗, affinity isolated antibody, buffered aqueous solution
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen ~110 kDa
species reactivity
human (predicted), mouse, rat
technique(s)
indirect immunofluorescence: 10-20 μg/mL using rat NRK and mouse NIH3T3 cells
western blot (chemiluminescent): 2.5-5 μg using whole extract of rat NRK cells
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... LAMP2(3920)
mouse ... Lamp2(16784)
rat ... Lamp2(24944)
Biochem/physiol Actions
溶酶体相关膜蛋白2(LAMP2)可促进细胞之间的粘附。也维持细胞稳态和应激。
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General description
LAMP2编码膜糖蛋白家族的成员。该糖蛋白为选择素提供碳水化合物配体。它可能在肿瘤细胞转移中发挥作用。它还可以在溶酶体的保护、维持和粘附中发挥作用。
LAMP2（溶酶体相关膜蛋白2）是一种在溶酶体膜上的高度糖基化的内源性蛋白(110kD)。蛋白糖基化对保护溶酶体膜免受溶酶体中的蛋白水解酶影响可能十分重要。抗LAMP2抗体可用于蛋白质免疫印迹。也用作溶酶体标记。兔抗LAMP2抗体可与小鼠和大鼠的LAMP2蛋白发生特异性反应。
溶酶体相关膜蛋白2(LAMP2) 基因位于人类染色体Xq24上。LAMP2 主要在溶酶体中表达。分为LAMP2A、LAMP2B和LAMP2C三种亚型。
Immunogen
对应于小鼠LAMP2的氨基酸残基404-415的合成肽，N-末端添加半胱氨酸，与KLH偶联。与大鼠中的相应序列相同，与人的相应序列相差2个氨基酸。
Physical form
0.01M 磷酸缓冲盐溶液，pH 7.4，含 15mM 叠氮化钠。
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存储类别
10 - Combustible liquids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
法规信息
常规特殊物品
此项目有
Two human lysosomal membrane glycoproteins, h-lamp-1 and h-lamp-2, are encoded by genes localized to chromosome 13q34 and chromosome Xq24-25, respectively.
Mattei MG, et al.
The Journal of Biological Chemistry, 265(13), 7548-7551 (1990)
Autoantibodies to hLAMP-2 in ANCA-negative pauci-immune focal necrotizing GN
Peschel A, et al.
Journal of the American Society of Nephrology, 25(3), 455-463 (2014)
Surface LAMP-2 is an endocytic receptor that diverts antigen internalized by human dendritic cells into highly immunogenic exosomes
Leone DA, et al.
Journal of Immunology, ji1601263-ji1601263 (2017)
Acute alloxan renal toxicity in the rat initially causes degeneration of thick ascending limbs of Henle
Terayama Y, et al.
Journal of Toxicologic Pathology (2016)
Ke-Qiong Deng et al.
Circulation, 137(14), 1486-1504 (2017-12-13)
Cardiac hypertrophy and its resultant heart failure are among the most common causes of mortality worldwide. Abnormal protein degradation, especially the impaired lysosomal degradation of large organelles and membrane proteins, is involved in the progression of cardiac hypertrophy. However, the
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