产品名称
抗 LAMP1 兔抗, affinity isolated antibody, buffered aqueous solution
Quality Level
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen ~120 kDa
species reactivity
rat, mouse, human
packaging
antibody small pack of 25 μL
technique(s)
indirect immunofluorescence: 5-10 μg/mL using human HeLa, rat NRK, and mouse NIH3T3 cells
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... LAMP1(3916)
mouse ... Lamp1(16783)
rat ... Lamp1(25328)
Disclaimer
除非我们的产品目录或产品随附的其他公司文件中另有说明，否则我们的产品仅用于研究用途，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、体外或体内治疗用途或任何类型的人类或动物消费或应用。
General description
基因 LAMP1 (溶酶体相关膜蛋白 1) 可编码一种 I 类跨膜蛋白，该蛋白有一个包含 GYQTI (382)-COOH 的溶酶体靶向信号的短胞浆尾。该基因定位于人类染色体13q34上。
溶酶体相关膜蛋白1（LAMP1），也称为Igp120，是高度糖基化的溶酶体膜蛋白，分子量约 120 kDa。由分子量约40 kDa的核心多肽组成，具有O型连接和18个天冬酰胺连接的寡糖侧链。LAMP1蛋白含前导序列、大内腔区（由2个同源结构域组成，这2个结构域由富含脯氨酸和丝氨酸的铰链区隔开）、跨膜区（含24个氨基酸）和胞质短尾区（包含溶酶体膜靶向信号）。LAMP1普遍表达，且高度保守。尽管可在细胞表面检测到小部分存在，但LAMP1主要定位于溶酶体。研究发现，与低转移性细胞相比，高转移性肿瘤细胞在细胞表面表达更多的LAMP分子。
Biochem/physiol Actions
LAMP1（溶酶体相关膜蛋白1）基因编码一种作为细胞内受体的膜糖蛋白。 有研究发现它在多种类型癌细胞的胞质中表达，并且可能参与肿瘤侵袭。Lamp1对于穿孔素进入溶解颗粒和这些溶解颗粒的运动至关重要。对其进行敲除会导致人类自然杀伤细胞的细胞毒性受到抑制。
高度糖基化的溶酶体相关膜蛋白1（LAMP1）对保护溶酶体膜免受溶酶体中的蛋白水解酶影响可能十分重要。
Application
兔抗-LAMP1-Cy3 ™ 抗体可用于免疫印迹和免疫荧光。
Immunogen
对应于人源LAMP1的氨基酸残基405-416的合成肽段，具有与KLH缀合的N-末端添加的半胱氨酸 - 甘氨酸。 相应的序列在大鼠和小鼠中是相同的。
Other Notes
Physical form
0.01M 磷酸缓冲盐溶液，pH 7.4，含 15mM 叠氮化钠。
Legal Information
Cy3 is a trademark of Cytiva
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存储类别
10 - Combustible liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
法规信息
常规特殊物品
此项目有
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